Apostolova Liana G, Cummings Jeffrey L
Department of Neurology, David Geffen School of Medicine, UCLA, USA.
Dement Geriatr Cogn Disord. 2008;25(2):115-26. doi: 10.1159/000112509. Epub 2007 Dec 14.
Mild cognitive impairment (MCI) is an etiologically heterogeneous condition that is characterized by cognitive changes without impairment of activities of daily living and insufficient to represent dementia. MCI is an important risk state for dementia. Neuropsychiatric symptoms may be present in MCI.
We executed a PubMed search for articles on the neuropsychiatric manifestations in MCI and reviewed their findings.
Behavioral abnormalities are reported in 35-75% of MCI patients with the most common being depression, apathy, anxiety and irritability. The observed variability in symptom prevalence can be explained by the different sampling methods, MCI diagnostic criteria and behavioral instruments used. There is a compelling body of evidence that MCI patients with behavioral features are more prone to develop Alzheimer's disease (AD) than patients without these features.
Neuropsychiatric symptoms are common features of MCI. The behavioral changes observed in MCI are similar to those of AD and may help identify the subgroup of MCI patients with prodromal AD. Large prospective longitudinal studies would greatly contribute to our understanding of the epidemiology, diagnostic and prognostic value of the neuropsychiatric features in MCI.
轻度认知障碍（MCI）是一种病因异质性疾病，其特征为认知改变，但日常生活活动未受损且不足以诊断为痴呆。MCI是痴呆的重要风险状态。MCI患者可能出现神经精神症状。
我们在PubMed上搜索关于MCI神经精神表现的文章并综述其研究结果。
35% - 75%的MCI患者报告有行为异常，最常见的是抑郁、淡漠、焦虑和易怒。观察到的症状患病率差异可通过不同的抽样方法、MCI诊断标准和所使用的行为评估工具来解释。有确凿证据表明，有行为特征的MCI患者比无这些特征的患者更易患阿尔茨海默病（AD）。
神经精神症状是MCI的常见特征。MCI中观察到的行为变化与AD相似，可能有助于识别前驱AD的MCI患者亚组。大型前瞻性纵向研究将极大地有助于我们理解MCI中神经精神特征的流行病学、诊断和预后价值。
