Mokos I, Pasini J, Hrstić I, Stern-Padovan R, Cacic Z, Knezevic N
Department of Urology, University, Hospital Center Zagreb, Zagreb, Croatia.
Transplant Proc. 2007 Dec;39(10):3533-5. doi: 10.1016/j.transproceed.2007.09.042.
Extracorporeal shock wave lithotripsy (ESWL) is a safe, effective method to treat urinary lithiasis. The success rate in ESWL depends on stone location, size, number, and fragility as well as calceal anatomy and patency of the urinary tract. An association of calcineurin inhibitors and uric acid urolithiasis has been reported in renal allograft recipients, but the mechanism remains unknown. Herein we have reported the case of 68-year-old male patient who developed cryptogenic cirrhosis and underwent liver transplantation. Seven years after transplantation, the patient was admitted to the hospital with right renal colic. An 8.9-mm radiolucent stone at the pyeloureteric junction was associated with moderate consecutive hydronephrosis. The second stone was located in a lower renal calyx. After a failed attempt at retrograde ureteral stenting, we performed a percutaneous nephrostomy. Antegrade pyelography with following ESWL treatment resulted in disintegration of the obstructive stone at the pyeloureteric junction. Afterward, we performed antegrade placement of a double-J stent. Residual stones in the lower renal calyx were successfully treated with a 3-month course of oral intake of a dissolution agent-potassium sodium hydrogen citrate. In this case, we have discussed ESWL and oral dissolution therapy of radiolucent stones in a hydronephrotic right kidney, which resulted in stone-free disease after 3 months of combined therapy. There was neither clinical nor biochemical damage to the transplanted liver.
体外冲击波碎石术(ESWL)是治疗尿路结石的一种安全、有效的方法。ESWL的成功率取决于结石的位置、大小、数量、易碎性以及肾盂解剖结构和尿路通畅情况。肾移植受者中已报道钙调神经磷酸酶抑制剂与尿酸尿路结石有关,但机制尚不清楚。在此,我们报告了一例68岁男性患者,该患者患有原因不明的肝硬化并接受了肝移植。移植后七年,该患者因右肾绞痛入院。肾盂输尿管交界处有一枚8.9毫米的透光结石,并伴有中度持续性肾积水。第二枚结石位于肾下盏。逆行输尿管支架置入术失败后,我们进行了经皮肾造瘘术。顺行肾盂造影并随后进行ESWL治疗导致肾盂输尿管交界处的梗阻性结石碎裂。之后,我们顺行置入了双J支架。肾下盏的残留结石通过口服溶石剂柠檬酸钾钠3个月疗程成功治疗。在本病例中,我们讨论了对右肾积水的透光结石进行ESWL和口服溶石治疗,联合治疗3个月后结石清除。移植肝脏既无临床损伤也无生化损伤。