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新生儿苯并芘印记对成年期苯并芘和苯巴比妥诱导肝微粒体酶的影响。

Impact of neonatal benzpyrene imprinting on liver microsomal enzyme induction by benzpyrene and phenobarbital in adulthood.

作者信息

Csaba G, Szeberényi S, Dobozy O

机构信息

Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.

出版信息

Acta Physiol Hung. 1991;78(2):151-5.

PMID:1808981
Abstract

A single neonatal treatment of rats with benzpyrene accounted for a durable induction of the liver microsomal enzyme (PSMO) system. Neonatal treatment with benzpyrene enhanced the inducing action of phenobarbital administrated in adulthood, but did not change the effect of benzpyrene treatment in the adult age. It follows that the imprinting and inducing effects of the neonatal benzpyrene treatment took different trends.

摘要

用苯并芘对大鼠进行单次新生期处理可持久诱导肝脏微粒体酶（PSMO）系统。新生期用苯并芘处理可增强成年期给予苯巴比妥的诱导作用，但不改变成年期苯并芘处理的效果。由此可见，新生期苯并芘处理的印记和诱导作用呈现不同趋势。

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