Newton Robert, Ziegler John, Casabonne Delphine, Beral Valerie, Mbidde Edward, Carpenter Lucy, Maxwell Parkin D, Wabinga Henry, Mbulaiteye Sam, Jaffe Harold
Epidemiology and Genetics Unit, Department of Health Sciences, University of York, York, UK.
Eur J Cancer Prev. 2007 Dec;16(6):555-8. doi: 10.1097/01.cej.0000243863.22137.b7.
As part of an epidemiological study of cancer in Uganda, we investigated social, sexual and reproductive factors in relation to the risk of cancer of the uterine cervix. Patients with all cancer types or with benign tumours were recruited from hospitals in Kampala, Uganda, interviewed about various demographic and lifestyle factors and tested for antibodies against the human immunodeficiency virus-1 (HIV). The case-control study reported here involves 702 HIV-seronegative women, 343 of whom were diagnosed with cancer of the uterine cervix. Key findings were that the risk of cervical cancer increased linearly with the number of pregnancies [chi2(1)=44.7; P<0.0001]; a woman reporting having had 10 or more children had a roughly seven-fold increase in risk of the tumour as compared with women reporting fewer than four pregnancies (odds ratio=7.1; 95% confidence interval 3.8-13.2). The risk also varied inversely with age at first reported sexual intercourse [chi2(1)=8.4; P=0.004], perhaps reflecting an earlier age of infection with human papillomavirus, the main causal agent. These results are in line with those reported from studies in other countries.
作为乌干达癌症流行病学研究的一部分，我们调查了与子宫颈癌风险相关的社会、性和生殖因素。从乌干达坎帕拉的医院招募患有所有癌症类型或良性肿瘤的患者，询问他们各种人口统计学和生活方式因素，并检测其针对人类免疫缺陷病毒1型（HIV）的抗体。本文报告的病例对照研究涉及702名HIV血清阴性女性，其中343人被诊断患有子宫颈癌。主要发现是，子宫颈癌风险随怀孕次数呈线性增加[χ²(1)=44.7；P<0.0001]；报告生育10个或更多孩子的女性患肿瘤的风险比报告怀孕次数少于4次的女性高出约7倍（优势比=7.1；95%置信区间3.8-13.2）。风险也与首次报告性行为的年龄呈反比[χ²(1)=8.4；P=0.004]，这可能反映了主要致病因子人乳头瘤病毒的较早感染年龄。这些结果与其他国家的研究报告一致。
