Chandrasekaran Victor Raj Mohan, Wan Chang-Hsin, Liu Li-Lian, Hsu Dur-Zong, Liu Ming-Yie
Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan.
Shock. 2008 Aug;30(2):217-21. doi: 10.1097/shk.0b013e318160dd6b.
Acetaminophen (APAP) overdose causes acute liver injury or even death in both humans and experimental animals. We investigated the effect of sesame oil on APAP-induced acute liver injury. Male Wistar rats were given APAP (1,000 mg/kg; orally) to induce acute liver injury. Acetaminophen significantly increased aspartate transaminase, alanine transaminase, lipid peroxidation, and superoxide anion and hydroxyl radical generation levels; it also induced glutathione depletion. Sesame oil (8 mL/kg; orally) did not alter the gastric absorption of APAP, but it inhibited all the parameters altered by APAP and protected the rats against APAP-induced acute liver injury. We hypothesize that sesame oil maintained the intracellular glutathione levels, reduced reactive oxygen species levels, and inhibited lipid peroxidation in rats with APAP-induced acute liver injury.
对乙酰氨基酚（APAP）过量服用会在人类和实验动物中导致急性肝损伤甚至死亡。我们研究了芝麻油对APAP诱导的急性肝损伤的影响。给雄性Wistar大鼠口服APAP（1000毫克/千克）以诱导急性肝损伤。对乙酰氨基酚显著提高了天冬氨酸转氨酶、丙氨酸转氨酶、脂质过氧化以及超氧阴离子和羟基自由基的生成水平；它还导致了谷胱甘肽耗竭。芝麻油（8毫升/千克；口服）并未改变APAP的胃吸收，但它抑制了APAP改变的所有参数，并保护大鼠免受APAP诱导的急性肝损伤。我们推测，芝麻油维持了APAP诱导的急性肝损伤大鼠的细胞内谷胱甘肽水平，降低了活性氧水平，并抑制了脂质过氧化。
