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[甲型肝炎感染合并潜在葡萄糖-6-磷酸脱氢酶缺乏症导致的急性溶血和肾衰竭]

[Acute hemolysis and renal failure caused by hepatitis A infection with underlying glucose-6-phosphate dehydrogenase deficiency].

作者信息

Jekarl Dong Wook, Oh Eun-Jee, Park Yeon-Joon, Han KyungJa, Lee Sung Won, Park Chong-Won

机构信息

Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

出版信息

Korean J Lab Med. 2007 Jun;27(3):188-91. doi: 10.3343/kjlm.2007.27.3.188.

Abstract

Although glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme disorder worldwide, it has rarely been reported among Korean. The patient was previously healthy 39 yr old male who showed severe hemolytic anemia and acute renal failure accompanied by hyperbilirubinemia after hepatitis A infection. The additional studies for differential diagnosis of hemolytic anemia showed a moderate deficiency of G6PD enzyme. Because hepatitis A infection in patient with G6PD deficiency present much more severe clinical symptoms, G6PD enzyme should be examined in patients with triggering factors of hemolysis such as hepatitis A infection.

摘要

尽管葡萄糖-6-磷酸脱氢酶(G6PD)缺乏症是全球最常见的酶紊乱疾病,但在韩国人中却鲜有报道。该患者为一名39岁此前健康的男性,在感染甲型肝炎后出现严重溶血性贫血、急性肾衰竭并伴有高胆红素血症。针对溶血性贫血进行鉴别诊断的进一步检查显示G6PD酶存在中度缺乏。由于G6PD缺乏症患者感染甲型肝炎后会出现更为严重的临床症状,因此对于有溶血性贫血触发因素(如感染甲型肝炎)的患者,应检查G6PD酶。

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