精神分裂症谱系障碍和双相情感障碍患者的血浆载脂蛋白E水平降低。
Plasma apolipoprotein E is decreased in schizophrenia spectrum and bipolar disorder.
作者信息
Dean Brian, Digney Alison, Sundram Suresh, Thomas Elizabeth, Scarr Elizabeth
机构信息
The Rebecca L. Cooper Research Laboratories, The Mental Health Research Institute, Parkville, Australia.
出版信息
Psychiatry Res. 2008 Feb 28;158(1):75-8. doi: 10.1016/j.psychres.2007.05.008. Epub 2007 Dec 21.
We have shown that plasma apolipoprotein E is significantly decreased in treatment-free subjects with schizophrenia spectrum and bipolar disorder but increases after treatment in bipolar disorder. Levels of apolipoprotein D were not changed by treatment. Hence changed apolipoprotein E could be involved in abnormalities in lipid homeostasis in some subjects with psychiatric diseases.
我们已经表明，在未接受治疗的精神分裂症谱系障碍和双相情感障碍患者中，血浆载脂蛋白E显著降低，但在双相情感障碍患者接受治疗后会升高。载脂蛋白D的水平不受治疗影响。因此，载脂蛋白E的变化可能与一些精神疾病患者脂质稳态异常有关。
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