使用F-18 FDG正电子发射断层扫描评估结核瘤的治疗反应。
Evaluation of therapeutic response of tuberculoma using F-18 FDG positron emission tomography.
作者信息
Park I-Nae, Ryu Jin-Sook, Shim Tae Sun
机构信息
Division of Pulmonology and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, Songpa-Gu, Seoul, Korea.
出版信息
Clin Nucl Med. 2008 Jan;33(1):1-3. doi: 10.1097/RLU.0b013e31815c5128.
BACKGROUND
Monitoring the response to antituberculosis (anti-TB) treatment can be difficult in patients with tuberculoma. We have retrospectively assessed the ability of F-18 fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) to evaluate the response to anti-TB treatment in patients with tuberculoma.
METHODS
Two patients with tuberculoma underwent repeat PET scans during anti-TB treatment. Changes in maximal standard uptake value (SUV) of the tuberculoma on PET images were analyzed between 2 scans. Initial PET scans were performed before the start of anti-TB treatment (T0), and later scans were performed after completion of treatment (T1).
RESULTS
In a 57-year-old female patient with clinical TB, maximal SUV of tuberculoma on PET scan decreased from 2.6 (at T0) to an undetectable value (at T1) at an interval of 187 days. In a 60-year-old woman with biopsy-proven TB, maximal SUV of tuberculoma on PET scan decreased from 4.8 (at T0) to 1.1 (at T1) at an interval of 192 days.
CONCLUSION
PET scans may be useful for monitoring responses to anti-TB treatment in patients with tuberculoma.
背景
对于患有结核瘤的患者，监测抗结核治疗的反应可能具有挑战性。我们回顾性评估了F-18氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）评估结核瘤患者抗结核治疗反应的能力。
方法
两名结核瘤患者在抗结核治疗期间接受了重复PET扫描。分析了两次扫描之间PET图像上结核瘤的最大标准摄取值（SUV）的变化。初始PET扫描在抗结核治疗开始前（T0）进行，后期扫描在治疗完成后（T1）进行。
结果
在一名57岁临床诊断为结核病的女性患者中，PET扫描显示结核瘤的最大SUV从2.6（T0时）降至不可检测值（T1时），间隔时间为187天。在一名60岁经活检证实为结核病的女性患者中，PET扫描显示结核瘤的最大SUV从4.8（T0时）降至1.1（T1时），间隔时间为192天。
结论
PET扫描可能有助于监测结核瘤患者的抗结核治疗反应。
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