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[术后淋巴皮肤瘘、乳糜性腹水和乳糜胸——罕见但严重的并发症:病因、诊断及治疗选择]

[Post-surgical lymphocutaneous fistula, chylous ascites and chylothorax--infrequent but serious complications: etiology, diagnosis and therapeutic options].

作者信息

Benedix F, Lippert H, Meyer F

机构信息

Aus der Klinik für Chirurgie, Universitätsklinikum, Magdeburg, Deutschland.

出版信息

Zentralbl Chir. 2007 Dec;132(6):529-38. doi: 10.1055/s-2007-981364.

Abstract

Lymphorrhea is an uncommon but potentially life-threatening complication following surgical procedures which strongly influences the outcome of surgical patients. Persistent lymphocutaneous fistula is mainly associated with an increased risk of local infections and wound complications. Chylous ascites and chylothorax can result in malnutrition, metabolic deterioration and immunosuppression that increase postsurgical morbidity. Diagnosis can easily be made by the characteristic milky-beige appearance of chylous fluid. Laboratory investigation of the drainage fluid (chylomicrons, triglycerides) enables to confirm diagnosis. Initial therapy favors conservative measures including drainage, pressure dressings, total parenteral nutrition and diet modifications. But this takes sometimes several weeks to control the chylous leak and leads to prolonged hospitalisation. Surgical options are only recommended if conservative therapy fails. However, surgical re-interventions are associated with significant incidence of morbidity and mortality. In addition, surgery may occasionally fail to identify the leak. Some promising new techniques have recently been introduced (application of octreotide or etilefrine, low-dose radiotherapy, use of sclerosing agents, subatmospheric pressure dressings or percutaneous embolization of cisterna chyli), which - alone or in combination with well-established conservative measures - may have the potential to avoid surgical re-interventions. Prevention of lymphorrhea during primary operation is of major importance. The present study focuses on current diagnostic and therapeutic options in the treatment of lymphocutaneous fistula, chylous ascites and chylothorax as the most frequent entities of lymphorrhea.

摘要

淋巴漏是一种不常见但可能危及生命的手术后并发症,严重影响手术患者的预后。持续性淋巴皮肤瘘主要与局部感染和伤口并发症风险增加有关。乳糜腹水和乳糜胸可导致营养不良、代谢恶化和免疫抑制,从而增加术后发病率。通过乳糜液特有的乳白米色外观很容易做出诊断。对引流液进行实验室检查(乳糜微粒、甘油三酯)有助于确诊。初始治疗倾向于采取保守措施,包括引流、加压包扎、全胃肠外营养和饮食调整。但有时需要数周时间才能控制乳糜漏,导致住院时间延长。仅在保守治疗失败时才建议采取手术治疗。然而,再次手术干预会带来较高的发病率和死亡率。此外,手术有时可能无法找到漏口。最近引入了一些有前景的新技术(应用奥曲肽或乙苯福林、低剂量放疗、使用硬化剂、负压包扎或经皮栓塞乳糜池),这些技术单独使用或与成熟的保守措施联合使用,可能有避免再次手术干预的潜力。在初次手术期间预防淋巴漏至关重要。本研究重点关注淋巴皮肤瘘、乳糜腹水和乳糜胸这几种最常见的淋巴漏类型的当前诊断和治疗选择。

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