Sawka Anna M, Orlov Steven, Gelberg Jacob, Stork Barry, Dowar Mark, Shaytzag Michael, Tabatabaie Vafa, Freeman Jeremy L, Walfish Paul G
Medicine/Endocrine Division, University Health Network, Toronto, Ontario, Canada.
Head Neck. 2008 Jun;30(6):693-700. doi: 10.1002/hed.20755.
In well-differentiated thyroid carcinoma, predictors of future positivity of stimulated thyroglobulin (>2 microg/L) after initial radioactive iodine treatment are not known.
In a retrospective study, we used logistic regression analysis to determine whether postoperative stimulated thyroglobulin measurements and pathologic stage independently predict future stimulated thyroglobulin positivity.
We followed 141 patients with well-differentiated thyroid carcinoma for a median of 35 months; follow-up stimulated thyroglobulin measurements were positive in 20.6% (29/141). The natural logarithm of the postsurgical stimulated thyrogolobulin was independently associated with a positive stimulated thyroglobulin at long-term follow-up (odds ratio [OR], 4.44; 95% confidence interval [CI], 2.33-8.45; p < .001); there was a trend for a positive association of TNM stage with positive follow-up stimulated thyroglobulin (p = .054). Lymph node positivity predicted a positive stimulated thyroglobulin in papillary cancer.
Stimulated thyroglobulin measurements prior to initial radioactive iodine treatment independently predict future stimulated thyroglobulin positivity in well-differentiated thyroid carcinoma.
在分化型甲状腺癌中，初始放射性碘治疗后刺激甲状腺球蛋白（>2μg/L）未来阳性的预测因素尚不清楚。
在一项回顾性研究中，我们使用逻辑回归分析来确定术后刺激甲状腺球蛋白测量值和病理分期是否能独立预测未来刺激甲状腺球蛋白的阳性情况。
我们对141例分化型甲状腺癌患者进行了中位时间为35个月的随访；随访时刺激甲状腺球蛋白测量值呈阳性的患者占20.6%（29/141）。术后刺激甲状腺球蛋白的自然对数与长期随访时刺激甲状腺球蛋白呈阳性独立相关（优势比[OR]为4.44；95%置信区间[CI]为2.33 - 8.45；p <.001）；TNM分期与随访时刺激甲状腺球蛋白呈阳性有正相关趋势（p = 0.054）。淋巴结阳性预测乳头状癌中刺激甲状腺球蛋白呈阳性。
初始放射性碘治疗前刺激甲状腺球蛋白的测量值可独立预测分化型甲状腺癌未来刺激甲状腺球蛋白的阳性情况。
