Regulation of purine metabolism. Adenylosuccinate synthetase from Novikoff ascites tumor cells.
作者信息
Clark A W, Rudolph F B
出版信息
Biochim Biophys Acta. 1976 Jun 23;437(1):87-90. doi: 10.1016/0304-4165(76)90349-4.
PMID:181081
Abstract
Adenylosuccinate synthetase has been partially purified from Novikoff ascites tumor cells. The properties of the protein are quite different from the enzyme from rat liver in that the Km for asparate is higher and the K1 for the feedback inhibitor AMP is also higher. The antibiotic hadacidin has a preferential inhibitory effect on the tumor enzyme. These results suggest that the Novikoff ascites tumor enzyme is less sensitive to normal feedback controls but may be more sensitive to specific antitumor drugs.
摘要
相似文献
1
Regulation of purine metabolism. Adenylosuccinate synthetase from Novikoff ascites tumor cells.
Biochim Biophys Acta. 1976 Jun 23;437(1):87-90. doi: 10.1016/0304-4165(76)90349-4.
2
Purification, crystallization, and properties of adenylosuccinate synthetase from rat skeletal muscle.大鼠骨骼肌腺苷酸琥珀酸合成酶的纯化、结晶及性质
J Biochem. 1977 Apr;81(4):859-69. doi: 10.1093/oxfordjournals.jbchem.a131550.
3
Enzymes of the purine ribonucleotide cycle in rat hepatomas and kidney tumors.大鼠肝癌和肾癌中嘌呤核糖核苷酸循环的酶
Cancer Res. 1977 Sep;37(9):3057-65.
4
Regulatory effects of purine ribonucleotides on Escherichia coli adenylosuccinate synthase.
Arch Biochem Biophys. 1975 Jul;169(1):339-43. doi: 10.1016/0003-9861(75)90349-5.
5
6
Regulation of the biosynthesis of purine nucleotides in Schizosaccharomyces pombe. 3. Kinetic studies of adenylosuccinate synthetase.
Biochim Biophys Acta. 1973 May 5;309(1):1-10. doi: 10.1016/0005-2744(73)90311-2.
7
Neoplastic transformation-linked alterations in adenylosuccinate synthetase activity.与肿瘤转化相关的腺苷酸琥珀酸合成酶活性改变。
Biochem Biophys Res Commun. 1975 Sep 16;66(2):526-32. doi: 10.1016/0006-291x(75)90542-2.
8
Human adenylosuccinate synthetase. Partial purification, kinetic and regulatory properties of the enzyme from placenta.
J Biol Chem. 1974 Nov 25;249(22):7282-9.
9
Adenylosuccinate synthetase in rat liver: the existence of two types and their regulatory roles.大鼠肝脏中的腺苷琥珀酸合成酶：两种类型的存在及其调节作用。
Biochem Biophys Res Commun. 1977 Sep 23;78(2):766-71. doi: 10.1016/0006-291x(77)90245-5.
10
Differences between pyrimidine nucleoside monophosphate kinase from rat Novikoff ascites hepatoma and rat liver.大鼠诺维科夫腹水肝癌细胞与大鼠肝脏来源的嘧啶核苷单磷酸激酶之间的差异。
Cancer Res. 1976 Jul;36(7 PT 1):2312-6.
Zotero 插件