肾上腺切除术而非迷走神经切断术可逆转钙通道阻滞剂对大鼠乙醇诱导的胃损伤的恶化作用。

Adrenalectomy, but not vagotomy, reverses the worsening effect of Ca2+ blockers on ethanol-induced gastric lesions in rats.

作者信息

Glavin G B, Ogle C W

机构信息

Department of Pharmacology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.

出版信息

Eur J Pharmacol. 1991 Nov 26;205(2):171-5. doi: 10.1016/0014-2999(91)90816-9.

DOI:10.1016/0014-2999(91)90816-9

PMID:1812007

Abstract

This study examines the influence of the adrenals and of the vagus nerve on the lesion-worsening action of nitrendipine or verapamil on 75% ethanol-induced gastric mucosal damage in rats. Bilateral adrenalectomy antagonized ethanol lesion aggravation by nitrendipine or verapamil; instead, dose-related lesion reduction was seen. Dexamethasone treatment of adrenalectomized rats restored the lesion-enhancing effects of both Ca2+ channel blockers. Bilateral subdiaphragmatic vagotomy failed to abolish the adverse action of nitrendipine or verapamil on ethanol lesions. The findings suggest that the adrenal corticoids modulate the worsening effect of Ca2+ channel antagonists on ethanol-induced gastric damage; when the influence of the adrenal steroids is removed, these compounds become gastroprotective.

摘要

本研究考察了肾上腺和迷走神经对尼群地平或维拉帕米加重75%乙醇诱导的大鼠胃黏膜损伤作用的影响。双侧肾上腺切除术可拮抗尼群地平或维拉帕米对乙醇损伤的加重作用；相反，可见剂量相关的损伤减轻。对肾上腺切除大鼠给予地塞米松治疗可恢复两种钙通道阻滞剂的损伤增强作用。双侧膈下迷走神经切断术未能消除尼群地平或维拉帕米对乙醇损伤的不良作用。这些发现提示，肾上腺皮质激素可调节钙通道拮抗剂对乙醇诱导的胃损伤的加重作用；当去除肾上腺类固醇的影响时，这些化合物具有胃保护作用。