中枢黑皮质素-3-受体的选择性调节对食物摄入及下丘脑阿黑皮素原表达的影响。
Effects of selective modulation of the central melanocortin-3-receptor on food intake and hypothalamic POMC expression.
作者信息
Lee Michelle, Kim Andrea, Conwell Irene M, Hruby Victor, Mayorov Alexander, Cai Minying, Wardlaw Sharon L
机构信息
Department of Medicine, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA.
出版信息
Peptides. 2008 Mar;29(3):440-7. doi: 10.1016/j.peptides.2007.11.005. Epub 2007 Nov 21.
Abstract
Hypothalamic POMC neurons regulate energy balance via interactions with brain melanocortin receptors (MC-Rs). POMC neurons express the MC3-R which can function as an inhibitory autoreceptor in vitro. We now demonstrate that central activation of MC3-R with ICV infusion of the specific MC3-R agonist, [D-Trp(8)]-gamma-MSH, transiently suppresses hypothalamic Pomc expression and stimulates food intake in rats. Conversely, we also show that ICV infusion of a low dose of a selective MC3-R antagonist causes a transient decrease in feeding and weight gain. These data support a functional inhibitory role for the MC3-R on POMC neurons that leads to changes in food intake.
摘要
下丘脑促黑素原（POMC）神经元通过与脑黑皮质素受体（MC-Rs）相互作用来调节能量平衡。POMC神经元表达MC3-R，其在体外可作为抑制性自身受体发挥作用。我们现在证明，通过脑室内注射特异性MC3-R激动剂[D-Trp(8)]-γ-促黑素（MSH）对MC3-R进行中枢激活，可短暂抑制大鼠下丘脑Pomc表达并刺激其食物摄入。相反，我们还表明，脑室内注射低剂量的选择性MC3-R拮抗剂会导致进食和体重增加短暂减少。这些数据支持MC3-R对POMC神经元具有功能性抑制作用，从而导致食物摄入量发生变化。
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