儿茶酚-O-甲基转移酶（COMT）基因新的功能性单核苷酸多态性（丙氨酸72丝氨酸）与男性精神分裂症患者的攻击行为相关。
New functional single nucleotide polymorphism (Ala72Ser) in the COMT gene is associated with aggressive behavior in male schizophrenia.
作者信息
Hong Jin Pyo, Lee Joongsun S, Chung Seockhoon, Jung Jaeyeul, Yoo Hanik K, Chang Sung Man, Kim Chang Yoon
机构信息
Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
出版信息
Am J Med Genet B Neuropsychiatr Genet. 2008 Jul 5;147B(5):658-60. doi: 10.1002/ajmg.b.30649.
A new functional single nucleotide polymorphism (SNP) Ala72Ser in the COMT gene was discovered recently. The purpose of our study is to examine the association between Ala72Ser and Val158Met functional polymorphisms in COMT gene and homicidal behavior in schizophrenia. DNA was genotyped for the Ala72Ser and Val158Met SNPs of the COMT gene in a sample of 93 schizophrenic patients who committed homicide (H-SCZ) and 100 schizophrenic patients who had never committed homicide (NH-SCZ). A statistically significant difference was found in genotype distribution and allele frequencies in SNP Ala72Ser of COMT gene between H-SCZ and NH-SCZ group. In haplotype analysis, the frequency of the combination of high-high activity allele (Ala-Val) was lower in H-SCZ group than in NH-SCZ group (P = 0.000069). Our study showed a highly significant association between a COMT haplotype of two functional SNPs and aggressive behavior in schizophrenia.
最近发现了COMT基因中的一种新的功能性单核苷酸多态性（SNP）Ala72Ser。我们研究的目的是检验COMT基因中的Ala72Ser和Val158Met功能性多态性与精神分裂症患者杀人行为之间的关联。对93例有杀人行为的精神分裂症患者（H-SCZ）和100例从未有过杀人行为的精神分裂症患者（NH-SCZ）样本进行了COMT基因Ala72Ser和Val158Met SNPs的基因分型。H-SCZ组和NH-SCZ组之间，COMT基因SNP Ala72Ser的基因型分布和等位基因频率存在统计学显著差异。在单倍型分析中，高活性等位基因组合（Ala-Val）在H-SCZ组中的频率低于NH-SCZ组（P = 0.000069）。我们的研究表明，两种功能性SNP的COMT单倍型与精神分裂症患者的攻击行为之间存在高度显著的关联。
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