Resch Garth E, Simpson C Wayne
Division of Molecular Biology and Biochemistry, University of Missouri-Kansas City, Kansas City, MO 64110-2792, USA.
Peptides. 2008 Mar;29(3):430-9. doi: 10.1016/j.peptides.2007.11.009. Epub 2007 Nov 22.
Peptide inhibitors of ethanol consumption have shown promise. The purpose of this study was to test the cyclized form of the opioid-derived dipeptide, glycyl-L-glutamine to reduce ethanol consumption after either peripheral injections or site-specific injections into the nucleus accumbens (NAC) of high drinking and low drinking rats. Following I.P. cyclo-glycyl-glutamine (c-GQ), the data show a mean decrease in ethanol intake of 34.4% in P rats, and 39.4% in Sprague-Dawley rats at doses between 5 and 25mg/kg. The data show that peripherally administered c-GQ is effective in reducing ethanol consumption in both high (P) and low (SD) drinking strains of rats and suggests a therapeutic potential.
乙醇摄入肽抑制剂已显示出前景。本研究的目的是测试阿片类衍生二肽甘氨酰-L-谷氨酰胺的环化形式，在向高饮酒和低饮酒大鼠的伏隔核（NAC）进行外周注射或位点特异性注射后，是否能减少乙醇摄入。腹腔注射环化甘氨酰-谷氨酰胺（c-GQ）后，数据显示，在5至25mg/kg的剂量下，P大鼠的乙醇摄入量平均下降了34.4%，斯普拉格-道利大鼠的乙醇摄入量平均下降了39.4%。数据表明，外周给予c-GQ可有效降低高饮酒（P）和低饮酒（SD）大鼠品系的乙醇摄入量，并显示出治疗潜力。
