依托考昔用于甲状腺手术期间的疼痛管理——一项前瞻性、安慰剂对照研究。
Etoricoxib for pain management during thyroid surgery--a prospective, placebo-controlled study.
作者信息
Smirnov Grigori, Terävä Markku, Tuomilehto Henri, Hujala Kimmo, Seppänen Marjatta, Kokki Hannu
机构信息
Department of Otorhinolaryngology, Kuopio University Hospital, Kuopio, Finland.
出版信息
Otolaryngol Head Neck Surg. 2008 Jan;138(1):92-7. doi: 10.1016/j.otohns.2007.10.022.
OBJECTIVE
To assess the efficacy of etoricoxib in pain treatment during thyroid surgery.
DESIGN
Double-blind, placebo-controlled, randomized trial.
SETTING
A secondary-level central hospital in Finland.
PATIENTS
Sixty-nine consecutive patients (59 women) aged 18 to 70 years who underwent thyroid surgery.
INTERVENTIONS
Patients were randomized to receive etoricoxib 120 mg (n = 34) or placebo (n = 35) by mouth 60 minutes before surgery. After surgery oxycodone 2 mg administered intravenously was provided for rescue analgesia.
MAIN OUTCOME MEASURES
Oxycodone consumption during the first 6 (primary) and the 7 to 24 hours (secondary) after surgery.
RESULTS
During the first 6 hours, all patients in the placebo group and 31 of 34 patients in the etoricoxib group were given oxycodone for rescue analgesia (P = 0.072). In the 7 to 24 postsurgical hours, 25 of 35 patients in the placebo group versus 16 of 34 patients in the etoricoxib group needed rescue analgesics (mean difference 24%, 95% CI -1 to 47%, P = 0.039).
CONCLUSION
Etoricoxib 120 mg reduced pain in the 7 to 24 postsurgical time period but did not have opioid-sparing effect during the first 6 hours after surgery.
目的
评估依托考昔在甲状腺手术疼痛治疗中的疗效。
设计
双盲、安慰剂对照、随机试验。
地点
芬兰的一家二级中心医院。
患者
69例连续接受甲状腺手术的18至70岁患者（59例女性）。
干预措施
患者在手术前60分钟随机口服依托考昔120毫克（n = 34）或安慰剂（n = 35）。术后静脉注射2毫克羟考酮用于解救镇痛。
主要观察指标
术后前6小时（主要）和7至24小时（次要）的羟考酮消耗量。
结果
在前6小时内，安慰剂组的所有患者和依托考昔组34例患者中的31例接受了羟考酮解救镇痛（P = 0.072）。在术后7至24小时，安慰剂组35例患者中的25例与依托考昔组34例患者中的16例需要解救镇痛药（平均差异24%，95%置信区间-1至47%，P = 0.039）。
结论
120毫克依托考昔在术后7至24小时可减轻疼痛，但在术后前6小时没有减少阿片类药物用量的作用。
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