Kendrick Iain P, Harris Roger C, Kim Hyo Jeong, Kim Chang Keun, Dang Viet H, Lam Thanh Q, Bui Toai T, Smith Marcus, Wise John A
University of Chichester, College Lane, Chichester, West Sussex PO196PE, UK.
Amino Acids. 2008 May;34(4):547-54. doi: 10.1007/s00726-007-0008-3. Epub 2008 Jan 4.
Carnosine (Carn) occurs in high concentrations in skeletal muscle is a potent physico-chemical buffer of H+ over the physiological range. Recent research has demonstrated that 6.4 g x day(-1) of beta-alanine (beta-ala) can significantly increase skeletal muscle Carn concentrations (M-[Carn]) whilst the resultant change in buffering capacity has been shown to be paralleled by significant improvements in anaerobic and aerobic measures of exercise performance. Muscle carnosine increase has also been linked to increased work done during resistance training. Prior research has suggested that strength training may also increase M-[Carn] although this is disputed by other studies. The aim of this investigation is to assess the effect of 10 weeks resistance training on M-[Carn], and, secondly, to investigate if increased M-[Carn] brought about through beta-ala supplementation had a positive effect on training responses. Twenty-six Vietnamese sports science students completed the study. The subjects completed a 10-week resistance-training program whilst consuming 6.4 g x day(-1) of beta-ala (beta-ALG) or a matched dose of a placebo (PLG). Subjects were assessed prior to and after training for whole body strength, isokinetic force production, muscular endurance, body composition. beta-Alanine supplemented subjects increased M-[Carn] by 12.81 +/- 7.97 mmol x kg(-1) dry muscle whilst there was no change in PLG subjects. There was no significant effect of beta-ala supplementation on any of the exercise parameters measured, mass or % body fat. In conclusion, 10 weeks of resistance training alone did not change M-[Carn].
肌肽(Carn)在骨骼肌中含量很高,是生理范围内一种强大的H⁺物理化学缓冲剂。最近的研究表明,每天6.4克β-丙氨酸(β-ala)可显著提高骨骼肌肌肽浓度(M-[Carn]),同时缓冲能力的相应变化已被证明与无氧和有氧运动表现的显著改善平行。肌肉肌肽增加也与抗阻训练期间完成的工作量增加有关。先前的研究表明力量训练可能也会增加M-[Carn],尽管其他研究对此提出质疑。本研究的目的一是评估10周抗阻训练对M-[Carn]的影响,二是研究通过补充β-ala增加的M-[Carn]是否对训练反应有积极影响。26名越南体育科学专业学生完成了该研究。受试者完成了一个10周的抗阻训练计划,同时每天摄入6.4克β-丙氨酸(β-ALG)或等量的安慰剂(PLG)。在训练前后对受试者进行全身力量、等速力量产生、肌肉耐力、身体成分评估。补充β-丙氨酸的受试者干肌肉的M-[Carn]增加了12.81±7.97毫摩尔/千克,而PLG组受试者没有变化。补充β-ala对所测量的任何运动参数、体重或体脂百分比均无显著影响。总之,仅10周的抗阻训练并未改变M-[Carn]。