麻醉剂对兴奋性递质门控通道的作用。

Actions of anesthetics on excitatory transmitter-gated channels.

作者信息

Akk G, Mennerick S, Steinbach J H

机构信息

Department of Anesthesiology, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA.

出版信息

Handb Exp Pharmacol. 2008(182):53-84. doi: 10.1007/978-3-540-74806-9_3.

DOI:10.1007/978-3-540-74806-9_3

PMID:18175086

Abstract

Excitatory transmitter-gated receptors are found in three gene families: the glutamate ionotropic receptors, the Cys-loop receptor family (nicotinic and 5HT3), and the purinergic (P2X) receptors. Anesthetic drugs act on many members of these families, but in most cases the effects are unlikely to be related to clinically relevant anesthetic actions. However, the gaseous anesthetics (xenon and nitrous oxide) and the dissociative anesthetics (ketamine) have significant inhibitory activity at one type of glutamate receptor (the NMDA receptor) that is likely to contribute to anesthetic action. It is possible that some actions at neuronal nicotinic receptors may make a smaller contribution to effects of some anesthetics.

摘要

兴奋性递质门控受体存在于三个基因家族中

谷氨酸离子型受体、半胱氨酸环受体家族（烟碱型和5HT3）以及嘌呤能（P2X）受体。麻醉药物作用于这些家族的许多成员，但在大多数情况下，其作用不太可能与临床相关的麻醉作用有关。然而，气态麻醉剂（氙气和氧化亚氮）和解离麻醉剂（氯胺酮）对一种谷氨酸受体（NMDA受体）具有显著的抑制活性，这可能有助于麻醉作用。神经元烟碱型受体的某些作用可能对某些麻醉剂的效果贡献较小。