Lafont Olivier
Faculté de médecine et de pharmacie de Rouen, 22 boulevard Gambetta, 76183 Rouen 1.
Rev Hist Pharm (Paris). 2007 Jul;55(354):209-16. doi: 10.3406/pharm.2007.6334.
At the beginning was the willow bark, which was considered as a medicine by Hippocrates, Dioscorides and Plinus. During the XVIIIth century, the Reverend Edward Stone re-discovered the willow for the cure of agues. In 1829, the french pharmacist Pierre Joseph Leroux isolated salicin. Raffaelle Piria was the first to synthesize salicylic acid from salicin (salicoside). Hermann Kolbe prepared salicylic acid from sodium phenate and carbon dioxide. And then acetylsalicylic acid was first prepared by Charles Gerhardt in 1853, but he did not succeed in identifying its structure. Felix Hoffmann, Arthur Eichengrun and Heinrich Dresen from Bayer Laboratories were at the origin of the use of Aspirin as a medicine. In 1971, John Vane showed that aspirin-like drugs inhibited prostaglandine synthesis.
最初是柳树皮，希波克拉底、狄奥斯科里德斯和普林尼都将其视为一种药物。在18世纪，爱德华·斯通牧师重新发现柳树可用于治疗疟疾。1829年，法国药剂师皮埃尔·约瑟夫·勒鲁分离出了水杨苷。拉斐尔·皮里亚是第一个从水杨苷（水杨糖苷）合成水杨酸的人。赫尔曼·科尔贝用苯酚钠和二氧化碳制备了水杨酸。1853年，查尔斯·热拉尔首次制备了乙酰水杨酸，但他未能成功确定其结构。拜耳实验室的费利克斯·霍夫曼、亚瑟·艾兴格林和海因里希·德雷森是阿司匹林作为药物使用的起源。1971年，约翰·万恩表明，类似阿司匹林的药物会抑制前列腺素的合成。
