Allah Rakha, Yang Li, Li Sheng-bin
Key Laboratory of Forensic Sciences, National Ministry of Health, China.
Fa Yi Xue Za Zhi. 2007 Oct;23(5):373-9.
There is an increasing interest in single nucleotide polymorphism (SNP) typing in the forensic field. SNPs are very useful for defining Y chromosome or mtDNA haplotypes and DNA phenotyping. We focus on comparative advantages of SNP typing over length variations and expected number of loci required to gain probabilities equal to STR loci in use. This review also offers to the reader a state of the art of SNP genotyping technologies with the advantages and disadvantages of the different techniques and platforms for different forensic requirements.
在法医学领域,人们对单核苷酸多态性(SNP)分型的兴趣与日俱增。SNP对于定义Y染色体或线粒体DNA单倍型以及DNA表型分析非常有用。我们重点关注SNP分型相对于长度变异的比较优势,以及为获得与现行STR基因座相等的概率所需的预期基因座数量。本综述还向读者介绍了SNP基因分型技术的最新进展,以及不同技术和平台针对不同法医学需求的优缺点。