Luef Gerhard J
Department of Neurology, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Seizure. 2008 Mar;17(2):127-30. doi: 10.1016/j.seizure.2007.11.009. Epub 2008 Jan 3.
Sexual dysfunction is frequently reported by patients with epilepsy. Despite its fundamental role in human life, there has been surprisingly little research into the neurological control of human sexual behaviour. Multiple causes may lead to sexual dysfunction. The basis for hyposexuality has been attributed to both epilepsy and antiepileptic drug (AED) use, making it difficult to distinguish between the illness-specific and pharmacological impacts on sexual functioning. Low levels of androgens are associated with sexual arousal insufficiency and sexual dysfunction. When examining sexual dysfunction in men and women with epilepsy, the Arizona Sexual Experience Scale (ASEX) may be helpful in evaluating sexual function. Laboratory tests for oestrogen, free and total testosterone, and serum SHBG (sexhormone binding globuline) may also be useful in evaluating sexual health. Sporadic case studies suggest that hypersexuality is a rare but dramatic outcome of unilateral temporal lobectomy. Sexual seizure manifestations are also rare clinical phenomena during or after complex partial seizures that have received attention in the recent literature.
癫痫患者经常报告存在性功能障碍。尽管性在人类生活中具有根本作用,但令人惊讶的是,关于人类性行为的神经控制的研究却很少。多种原因可能导致性功能障碍。性欲减退的原因既归因于癫痫本身,也归因于抗癫痫药物(AED)的使用,这使得难以区分疾病特异性和药物对性功能的影响。雄激素水平低与性唤起不足和性功能障碍有关。在检查癫痫男性和女性的性功能障碍时,亚利桑那性体验量表(ASEX)可能有助于评估性功能。雌激素、游离睾酮和总睾酮以及血清性激素结合球蛋白(SHBG)的实验室检测也可能有助于评估性健康。零星的病例研究表明,性欲亢进是单侧颞叶切除术后罕见但显著的结果。性发作表现也是复杂部分性发作期间或之后罕见的临床现象,最近的文献对此有所关注。