Westin Andreas Austgulen, Reimers Arne, Helde Grethe, Nakken Karl Otto, Brodtkorb Eylert
Department of Clinical Pharmacology, St. Olavs Hospital, Olav Kyrres gate 17, N-7006 Trondheim, Norway.
Seizure. 2008 Mar;17(2):192-8. doi: 10.1016/j.seizure.2007.11.027. Epub 2008 Jan 3.
To investigate changes in levetiracetam (LEV) serum concentration/dose ratio (C/D-ratio) in relation to pregnancy.
Altogether 21 consecutive pregnancies in 20 women with epilepsy receiving LEV during gestation were studied retrospectively. The main target variable was the C/D-ratio before and during pregnancy, and in the post partum period. Secondary target variables were changes in LEV dose, concomitant use of other antiepileptic drugs and seizure frequency. Student's paired t-test and two-sample t-test for independent samples were used to test for statistically significant changes in C/D-ratio means.
Mean C/D-ratio in the third trimester was 50% of the mean C/D-ratio at baseline (p<0.001, n=11). Baseline levels were reached within the first weeks after pregnancy. The interindividual variability was pronounced.
Serum concentrations of LEV declined significantly in the third trimester of pregnancy and increased rapidly after delivery.
研究左乙拉西坦（LEV）血清浓度/剂量比（C/D比）与妊娠相关的变化。
回顾性研究了20名在妊娠期接受LEV治疗的癫痫女性的21次连续妊娠。主要目标变量是妊娠前、妊娠期间及产后的C/D比。次要目标变量是LEV剂量的变化、其他抗癫痫药物的联合使用情况及癫痫发作频率。采用学生配对t检验和独立样本双样本t检验来检验C/D比均值的统计学显著变化。
孕晚期的平均C/D比为基线时平均C/D比的50%（p<0.001，n = 11）。妊娠后的头几周内达到基线水平。个体间差异明显。
妊娠晚期LEV的血清浓度显著下降，产后迅速升高。
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