Taşkiran Emin, Ozçelik Cağri
Ege Universitesi Tip Fakültesi Ortopedi ve Travmatojoji Anabilim Dali, Izmir, Turkey.
Acta Orthop Traumatol Turc. 2007;41 Suppl 2:70-8.
The surface of diarthrodial joints is covered by hyaline cartilage whose regeneration capacity is extremely limited. Conventional surgical techniques enable repair of full-thickness articular cartilage defects only by fibrous cartilage having poor mechanical properties. Recently, new techniques have been developed to provide hyaline or hyaline-like repair tissue in the treatment of full-thickness cartilage defects. Autologous osteochondral transplantation involves press-fit implantation of both bone and cartilage obtained from healthy articular surface. The principal indication for this technique is unifocal full-thickness chondral or osteochondral defects measuring 1 to 4 square centimeters. This surgical procedure can be performed openly or arthroscopically. The graft should be placed vertically and evenly to the joint surface. Although short-term and mid-term results are satisfactory, several problems have been reported including donor site morbidity, damage to cartilage, and incongruity and incorporation of the graft. Autologous osteochondral transplantation provides viable osteochondral units at a single stage and eliminates the need for culturing chondrocytes which is quite expensive. Currently, no surgical technique or medical treatment provide complete healing of articular cartilage defects. Autologous osteochondral transplantation is an important stage worthy of improvement in this respect.
动关节的表面覆盖着透明软骨,其再生能力极其有限。传统的外科技术仅能通过机械性能较差的纤维软骨来修复全层关节软骨缺损。最近,已开发出新技术,以便在治疗全层软骨缺损时提供透明或类似透明的修复组织。自体骨软骨移植包括将从健康关节表面获取的骨和软骨压配植入。该技术的主要适应证是面积为1至4平方厘米的单灶性全层软骨或骨软骨缺损。此手术可通过开放或关节镜方式进行。移植物应垂直且均匀地放置于关节表面。尽管短期和中期结果令人满意,但仍有一些问题被报道,包括供区并发症、软骨损伤以及移植物的不匹配和整合问题。自体骨软骨移植可在单一阶段提供有活力的骨软骨单元,且无需培养软骨细胞,而培养软骨细胞成本相当高。目前,尚无手术技术或药物治疗能实现关节软骨缺损的完全愈合。自体骨软骨移植在这方面是值得改进的一个重要阶段。