急性α肾上腺素能刺激对心脏功能的影响。
Effect of acute alpha adrenergic stimulation on cardiac function.
作者信息
Dunaway Stacy, Yu Qianli, Larson Douglas F
机构信息
Sarver Heart Center, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA.
出版信息
Perfusion. 2007 Jul;22(4):289-92. doi: 10.1177/0267659107084145.
BACKGROUND
Phenylephrine (PE) is a alpha-adrenergic agent commonly administered by perfusion and anesthesia. It is important to identify the effect of PE, especially on cardiac function. This study was intended to show the effects of PE on cardiac function in the murine model via pressure-volume loops.
METHODS
Six C57BL/6J twelve-week-old female mice were studied prior to and following PE administration at 50 microg/kg IV. In vivo pressure-volume loops were recorded at both time points.
RESULTS
There was an expected increase in maximum arterial pressure by 30% (p < 0.001) and end-systolic pressure by 34% (p < 0.001). However, there was a decrease in cardiac output by 30% (p = 0.0006), ejection fraction by 36% (p = 0.0003) and stroke volume by 25% (p < 0.004).
CONCLUSIONS
This study demonstrates that PE has an effect on cardiac function beyond increasing vascular resistance. The data suggest the negative effects of PE on cardiac function may be related to stimulation of cardiac alpha-adrenergic receptors.
背景
去氧肾上腺素（PE）是一种常用于灌注和麻醉的α-肾上腺素能药物。确定PE的作用，尤其是对心脏功能的作用非常重要。本研究旨在通过压力-容积环展示PE对小鼠模型心脏功能的影响。
方法
对6只12周龄的C57BL/6J雌性小鼠在静脉注射50μg/kg PE之前和之后进行研究。在两个时间点记录体内压力-容积环。
结果
最大动脉压预期升高30%（p < 0.001），收缩末期压力升高34%（p < 0.001）。然而，心输出量降低30%（p = 0.0006），射血分数降低36%（p = 0.0003），每搏输出量降低25%（p < 0.004）。
结论
本研究表明，PE对心脏功能的影响不仅仅是增加血管阻力。数据表明，PE对心脏功能的负面影响可能与心脏α-肾上腺素能受体的刺激有关。
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