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1
Evolution of GITRL immune function: murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily.
Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):635-40. doi: 10.1073/pnas.0710529105. Epub 2008 Jan 8.
2
Atypical TNF-TNFR superfamily binding interface in the GITR-GITRL complex for T cell activation.
Cell Rep. 2021 Sep 21;36(12):109734. doi: 10.1016/j.celrep.2021.109734.
3
Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function.
Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19452-7. doi: 10.1073/pnas.0709264104. Epub 2007 Nov 26.
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Structural basis for ligand-mediated mouse GITR activation.
Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):641-5. doi: 10.1073/pnas.0711206105. Epub 2008 Jan 4.
5
1.8 A structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells.
Acta Crystallogr D Biol Crystallogr. 2009 May;65(Pt 5):434-9. doi: 10.1107/S0907444909005721. Epub 2009 Apr 18.
7
GITR ligand fusion protein agonist enhances the tumor antigen-specific CD8 T-cell response and leads to long-lasting memory.
J Immunother Cancer. 2017 Jun 20;5:47. doi: 10.1186/s40425-017-0247-0. eCollection 2017.
9
Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states.
Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5465-70. doi: 10.1073/pnas.0711350105. Epub 2008 Mar 31.
10
Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells.
Biochem Biophys Res Commun. 2003 Oct 17;310(2):433-8. doi: 10.1016/j.bbrc.2003.09.024.

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2
Development of a fully human anti-GITR antibody with potent antitumor activity using H2L2 mice.
FEBS Open Bio. 2022 Aug;12(8):1542-1557. doi: 10.1002/2211-5463.13451. Epub 2022 Jun 21.
4
An anti-PD-1-GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy.
Nat Cancer. 2022 Mar;3(3):337-354. doi: 10.1038/s43018-022-00334-9. Epub 2022 Mar 7.
6
Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions.
Nat Commun. 2021 Mar 2;12(1):1378. doi: 10.1038/s41467-021-21563-z.
8
HERA-GITRL activates T cells and promotes anti-tumor efficacy independent of FcγR-binding functionality.
J Immunother Cancer. 2019 Jul 19;7(1):191. doi: 10.1186/s40425-019-0671-4.
9
Genetically modified hematopoietic stem/progenitor cells that produce IL-10-secreting regulatory T cells.
Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2634-2639. doi: 10.1073/pnas.1811984116. Epub 2019 Jan 25.

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1
Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function.
Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19452-7. doi: 10.1073/pnas.0709264104. Epub 2007 Nov 26.
2
GITR/GITRL: more than an effector T cell co-stimulatory system.
Eur J Immunol. 2007 May;37(5):1165-9. doi: 10.1002/eji.200636933.
4
The crystal structure of the costimulatory OX40-OX40L complex.
Structure. 2006 Aug;14(8):1321-30. doi: 10.1016/j.str.2006.06.015.
5
The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity?
Nat Rev Immunol. 2006 Aug;6(8):613-8. doi: 10.1038/nri1867.
6
Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human.
J Biol Chem. 2006 May 19;281(20):13964-71. doi: 10.1074/jbc.M601553200. Epub 2006 Mar 17.
8
TNF/TNFR family members in costimulation of T cell responses.
Annu Rev Immunol. 2005;23:23-68. doi: 10.1146/annurev.immunol.23.021704.115839.

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