Kimoto M, Sakamoto M, Iyatomi H, Tanaka M
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
Dermatology. 2008;216(3):205-12. doi: 10.1159/000112927. Epub 2008 Jan 9.
Acral melanocytic nevi have parallel patterns on dermoscopy; however, it is not understood why pigment distributions exhibit such patterns.
To clarify the reason why melanin distributions in acral melanocytic nevi exhibit a parallel pattern on dermoscopy.
A serial sectioning perpendicular to the skin markings was performed, and each section was stained with modified Fontana-Masson staining to pick out melanin granules. These sections were then reconstructed to three-dimensional images by an image processing software, and these three-dimensional images were analyzed.
Melanin columns in the cornified layer were mainly seen in the dermoscopic images of acral melanocytic nevi. In the parallel-furrow pattern melanin columns were arranged vertically, and in the fibrillar pattern they were arranged in a slanting fashion.
Melanin columns in the cornified layer, not melanin in the basal layer, mainly contribute to the dermoscopic pattern of acral melanocytic nevi.
肢端黑素细胞痣在皮肤镜下呈现平行模式；然而，目前尚不清楚色素分布为何呈现这种模式。
阐明肢端黑素细胞痣中黑色素分布在皮肤镜下呈现平行模式的原因。
进行垂直于皮肤纹理的连续切片，每片用改良的Fontana-Masson染色以挑选出黑色素颗粒。然后通过图像处理软件将这些切片重建为三维图像，并对这些三维图像进行分析。
在肢端黑素细胞痣的皮肤镜图像中主要可见角质层中的黑色素柱。在平行沟纹模式中，黑色素柱垂直排列，而在纤维状模式中，它们呈倾斜排列。
角质层中的黑色素柱而非基底层中的黑色素，主要促成了肢端黑素细胞痣的皮肤镜模式。
