Krysiak Robert, Okopień Bogusław, Herman Zbigniew Stanisław
Katedra Farmakologii, Zakład Farmakologii Klinicznej Slaskiej Akademii Medycznej, Katowice.
Przegl Lek. 2007;64(1):31-6.
In light of research carried during the past 15 years, it has become obvious that primary aldosteronism occurs much more frequently than previously estimated. This increase in its prevalence reflects a wider screening of patients for primary aldosteronism, especially with the use of the aldosterone to renin ratio. Currently many authors consider the disease as the most frequent recognisable and treatable cause of secondary hypertension. Although, primary aldosteronism is usually associated with hypertension and hypokalemia, many patients are either asymptomatic or manifest only slight symptoms. Early diagnosis and specific treatment reduce the morbidity and mortality related to this potentially life-threatening disorder. In this review, aetiology, symptoms, diagnosis and treatment of primary aldosteronism are reviewed with a special emphasis on the most recent literature.
根据过去15年的研究,原发性醛固酮增多症的发生频率比之前估计的要高得多,这一点已变得很明显。其患病率的增加反映了对原发性醛固酮增多症患者进行了更广泛的筛查,尤其是使用醛固酮与肾素比值进行筛查。目前,许多作者认为该病是继发性高血压最常见的可识别和可治疗病因。虽然原发性醛固酮增多症通常与高血压和低钾血症有关,但许多患者要么无症状,要么仅表现出轻微症状。早期诊断和特异性治疗可降低与这种潜在危及生命疾病相关的发病率和死亡率。在这篇综述中,我们回顾了原发性醛固酮增多症的病因、症状、诊断和治疗,并特别强调了最新的文献。