Leitgeb N
Institute of Healthcare Engineering and European Notified Body of Medical Devices, Graz University of Technology, Inffeldgasse 18, A-8010 Graz, Austria.
Phys Med Biol. 2008 Jan 21;53(2):431-43. doi: 10.1088/0031-9155/53/2/010. Epub 2007 Dec 28.
Electromagnetic fields both in daily life and at workplaces exhibit increasingly complex frequency spectra. Present spectral assessment rules proved to be too conservative for health risk assessment. This is because they are based on the assumption that cells would react like linear systems in terms of responding to a sum of frequencies by a sum of independent responses to each individual frequency. Based on numerical investigations with the Hodgkin-Huxley and the Frankenhaeuser-Huxley nerve cell models, it could be shown that accounting for the nonlinear behaviour of cellular excitation processes avoids considerable overestimation of simultaneous exposures to multiple frequency ELF electric and magnetic fields. Besides this, it could be shown that the role of phase relationships is less important than that assumed so far. The present assessment rules lead to non-compliances of marketed electric appliances. For general application, a nonlinear biology-based assessment (NBBA) rule has been proposed, validated and proven advantageous compared with ICNIRP's rule. While staying conservative it avoids unnecessary overestimation and demonstrates compliance even in cases of suspected non-conformities. It is up to responsible bodies to decide upon the adoption of this proposal and the potential need for implementing additional or reducing the already incorporated safety factors.
日常生活和工作场所中的电磁场频谱日益复杂。事实证明,目前的频谱评估规则在健康风险评估方面过于保守。这是因为它们基于这样一种假设,即细胞在对频率总和的反应方面会像线性系统一样,对每个单独频率的独立反应进行求和。基于对霍奇金-赫胥黎和弗兰肯海泽-赫胥黎神经细胞模型的数值研究,可以表明,考虑细胞兴奋过程的非线性行为可避免对同时暴露于多个频率的极低频电场和磁场的显著高估。除此之外,可以表明相位关系的作用没有迄今为止所认为的那么重要。目前的评估规则导致市场上的电器不符合规定。为了普遍应用,已经提出、验证并证明了一种基于非线性生物学的评估(NBBA)规则比国际非电离辐射防护委员会(ICNIRP)的规则更具优势。在保持保守的同时,它避免了不必要的高估,并且即使在疑似不符合的情况下也能证明符合规定。由负责机构决定是否采用该提案以及是否有必要实施额外的或减少已经纳入的安全系数。