Vanderah David J, Walker Marlon L, Rocco Mark A, Rubinson Kenneth A
Biochemical Science Division, Chemical Science and Technology Laboratory, National Institute of Standards and Technology (NIST), Gaithersburg, Maryland 20899, USA.
Langmuir. 2008 Feb 5;24(3):826-9. doi: 10.1021/la7028824. Epub 2008 Jan 11.
Self-assembled monolayers (SAMs) of the disulfide [S(CH2CH2O)6CH3]2 ([S(EO)6]2) on Au from 95% ethanol and from 100% water are described. Spectroscopic ellipsometry and reflection-absorption infrared spectroscopy indicate that the [S(EO)6]2 films are similar to the disordered films of HS(CH2CH2O)6CH3 ((EO)6) and HS(CH2)3O(CH2CH2O)5CH3 (C3EO5) at their protein adsorption minima. The [S(EO)6]2 SAMs exhibit constant film thickness (d) of 1.2 +/- 0.2 nm over long immersion times (up to 20 days) and do not attain the highly ordered, 7/2 helical structure of the (EO)6 and C3EO5 SAMs (d = 2.0 nm). Exposure of these self-limiting [S(EO)6]2 SAMs to bovine serum albumin show high resistance to protein adsorption.
描述了二硫化物[S(CH₂CH₂O)₆CH₃]₂([S(EO)₆]₂)在金表面自95%乙醇和100%水体系中形成的自组装单分子层(SAM)。椭圆偏振光谱和反射吸收红外光谱表明，在蛋白质吸附最小值处，[S(EO)₆]₂膜与HS(CH₂CH₂O)₆CH₃((EO)₆)和HS(CH₂)₃O(CH₂CH₂O)₅CH₃(C₃EO₅)的无序膜相似。[S(EO)₆]₂自组装单分子层在长时间浸泡(长达20天)后膜厚(d)保持恒定，为1.2±0.2nm，且未形成(EO)₆和C₃EO₅自组装单分子层的高度有序的7/2螺旋结构(d = 2.0nm)。将这些自限性的[S(EO)₆]₂自组装单分子层暴露于牛血清白蛋白时，显示出对蛋白质吸附的高抗性。
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