孟加拉国的砷暴露与贫血：一项基于人群的研究。
Arsenic exposure and anemia in Bangladesh: a population-based study.
作者信息
Heck Julia E, Chen Yu, Grann Victor R, Slavkovich Vesna, Parvez Faruque, Ahsan Habibul
机构信息
Department of Epidemiology, Mailman School of Public Health, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
出版信息
J Occup Environ Med. 2008 Jan;50(1):80-7. doi: 10.1097/JOM.0b013e31815ae9d4.
OBJECTIVE
The purpose of this study was to examine the association between arsenic exposure and anemia, based on blood hemoglobin concentration.
METHODS
Hemoglobin measures, skin lesions, arsenic exposure, and nutritional and demographic information were collected from 1954 Bangladeshi participants in the Health Effects of Arsenic Longitudinal Study. We used general linear modeling to assess the association between arsenic exposure and hemoglobin concentration, examining men and women separately.
RESULTS
Arsenic exposure (urinary arsenic >200 microg/L) was negatively associated with hemoglobin among all men and among women with hemoglobin <10 d/L. Other predictors of anemia in men and women included older age, lower body mass index, and low intake of iron. Among women, the use of contraceptives predicted higher hemoglobin.
CONCLUSIONS
The study suggests an association between high arsenic exposure and anemia in Bangladesh.
目的
本研究旨在基于血液血红蛋白浓度，探讨砷暴露与贫血之间的关联。
方法
从参与砷的健康影响纵向研究的1954名孟加拉国参与者中收集血红蛋白测量值、皮肤病变、砷暴露以及营养和人口统计学信息。我们使用一般线性模型来评估砷暴露与血红蛋白浓度之间的关联，并分别对男性和女性进行研究。
结果
在所有男性以及血红蛋白<10 d/L的女性中，砷暴露（尿砷>200微克/升）与血红蛋白呈负相关。男性和女性贫血的其他预测因素包括年龄较大、体重指数较低以及铁摄入量低。在女性中，使用避孕药可预测血红蛋白水平较高。
结论
该研究表明孟加拉国高砷暴露与贫血之间存在关联。
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