Desai Premal J, Castle Erik P, Daley Shane M, Swanson Scott K, Ferrigni Robert G, Humphreys Mitchell R, Andrews Paul E
Department of Urology, Mayo Clinic, Phoenix, AZ 85054, USA.
BJU Int. 2008 Apr;101(8):1019-23. doi: 10.1111/j.1464-410X.2007.07423.x. Epub 2008 Jan 10.
To present our experience with bilateral laparoscopic nephrectomy (BLN) for symptomatic autosomal-dominant polycystic kidney disease (ADPKD), as surgical management of massively enlarged polycystic kidneys can be a daunting task.
The study was a retrospective chart review of all patients undergoing BLN for ADPKD. Patient demographics, indications for the procedure, perioperative data, and pathological data were analysed.
In all, 12 patients underwent BLN at our institution; eight were performed before transplant, three after transplant, and one with a concomitant kidney transplant. Indications for surgery included abdominal pain, fullness and early satiety, recurrent urinary tract infections, and need for space for future transplant. The mean patient age was 49.6 years, with a body mass index of 27.0 kg/m(2). The mean operative duration was 214 min, estimated blood loss was 169 mL, and the hospital stay was 4 days. There were no conversions to open surgery. The mean (range) pathological kidney mass was 2243 (656-4200) g on the left and 2379 (789-5042) g on the right. No patients with a previous renal transplant had deterioration in postoperative renal function. There was one minor intraoperative complication, one postoperative complication, and one patient with preoperative anaemia required a blood transfusion.
Symptomatic patients with ADPKD due to massively enlarged kidneys should be considered for BLN when performed by an experienced laparoscopic surgeon. This includes patients with an existing renal allograft and candidates for concomitant transplantation. The approach should be tailored to avoid injury to adjacent structures secondary to displacement from the mass effect of these kidneys.
介绍我们对有症状的常染色体显性多囊肾病(ADPKD)患者行双侧腹腔镜肾切除术(BLN)的经验,因为对巨大多囊肾的手术治疗可能是一项艰巨的任务。
本研究是对所有因ADPKD接受BLN的患者进行的回顾性病历审查。分析了患者的人口统计学资料、手术指征、围手术期数据和病理数据。
共有12例患者在我院接受了BLN;8例在移植前进行,3例在移植后进行,1例同时进行肾移植。手术指征包括腹痛、腹胀和早饱感、反复尿路感染以及为未来移植预留空间的需求。患者平均年龄为49.6岁,体重指数为27.0kg/m²。平均手术时间为214分钟,估计失血量为169毫升,住院时间为4天。无中转开腹手术病例。左侧病理肾质量平均(范围)为2243(656 - 4200)克,右侧为2379(789 - 5042)克。既往有肾移植史的患者术后肾功能均未恶化。有1例轻微术中并发症、1例术后并发症,1例术前贫血患者需要输血。
对于因肾脏巨大而出现症状的ADPKD患者,由经验丰富的腹腔镜外科医生进行BLN时应予以考虑。这包括现有肾移植受者以及同时进行移植的候选者。手术方法应进行调整,以避免因这些肾脏的占位效应导致移位而损伤相邻结构。