铜绿假单胞菌MexAB - OprM外排泵在对茶树（互叶白千层）油及其单萜成分萜品-4-醇、1,8-桉叶素和α-松油醇耐受性中的作用
Role of the MexAB-OprM efflux pump of Pseudomonas aeruginosa in tolerance to tea tree (Melaleuca alternifolia) oil and its monoterpene components terpinen-4-ol, 1,8-cineole, and alpha-terpineol.
作者信息
Papadopoulos Chelsea J, Carson Christine F, Chang Barbara J, Riley Thomas V
机构信息
Discipline of Microbiology and Immunology M502, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, Western Australia 6009, Australia.
出版信息
Appl Environ Microbiol. 2008 Mar;74(6):1932-5. doi: 10.1128/AEM.02334-07. Epub 2008 Jan 11.
Abstract
Using a series of efflux mutants of Pseudomonas aeruginosa, the MexAB-OprM pump was identified as contributing to this organism's tolerance to the antimicrobial agent tea tree (Melaleuca alternifolia) oil and its monoterpene components terpinen-4-ol, 1,8-cineole, and alpha-terpineol. These data show that a multidrug efflux system of P. aeruginosa can extrude monoterpenes and related alcohols.
摘要
利用一系列铜绿假单胞菌的外排突变体，MexAB - OprM泵被确定为该生物体对抗菌剂茶树（互叶白千层）油及其单萜成分萜品-4-醇、1,8-桉叶素和α-萜品醇具有耐受性的原因。这些数据表明，铜绿假单胞菌的多药外排系统可以排出单萜和相关醇类。
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