通过3,5-二溴-2-吡喃酮的区域选择性施蒂勒偶联反应和狄尔斯-阿尔德反应全合成(±)-番木鳖碱
Total synthesis of (+/-)-crinine via the regioselective Stille coupling and Diels-Alder reaction of 3,5-dibromo-2-pyrone.
作者信息
Tam Nguyen Thanh, Cho Cheon-Gyu
机构信息
Department of Chemistry, Hanyang University, Seoul, Korea 133-791.
出版信息
Org Lett. 2008 Feb 21;10(4):601-3. doi: 10.1021/ol702907u. Epub 2008 Jan 15.
PMID:18193882
Abstract
The regioselective synthesis and Diels-Alder cycloaddition of 3-(3,4-methylenedioxyphenyl)-5-bromo-2-pyrone provided a new synthetic route to crinine. The vinyl bromide group can be used as a handle for further derivatization.
摘要
3-(3,4-亚甲二氧基苯基)-5-溴-2-吡喃酮的区域选择性合成及狄尔斯-阿尔德环加成反应为育亨宾碱提供了一条新的合成路线。乙烯基溴基团可作为进一步衍生化的官能团。
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