Lanitis Sophocles, Filippakis George, Thomas Johanna, Christofides Thalis, Al Mufti Ragheed, Hadjiminas Dimitri J
Breast Care Unit, Mary Stanford Wing, 5th Floor, St. Mary's Hospital-NHS Trust, Praed Street, London W2 1NY, UK.
Breast. 2008 Jun;17(3):309-13. doi: 10.1016/j.breast.2007.11.008. Epub 2008 Jan 22.
This study evaluates microdochectomy as a means for diagnosis and treatment of patients with pathological nipple discharge (PND) but with benign or normal imaging and cytology. From 1999 until 2006, in St. Mary's Hospital, 76 patients with the aforementioned condition underwent microdochectomy because of the presence of epithelial cells on nipple smear or for symptomatic relief. Most of the patients had intraductal papillomas (48.7%), duct ectasia (15.8%) or a combination of the two (13.2%). Other benign causes occurred in 11.8% of the patients. Eight patients, including one who was operated for symptomatic relief, had cancer. Of those patients with benign condition, 98% had symptomatic relief while PND recurred twice in one patient. Pre-operative workup and imaging may not be suspicious in patients with single-duct PND and underlying malignancy, therefore, microdochectomy should be considered in such cases.
本研究评估了微小乳管切除术作为诊断和治疗病理性乳头溢液（PND）但影像学和细胞学检查为良性或正常的患者的一种方法。1999年至2006年期间，在圣玛丽医院，76例患有上述情况的患者因乳头涂片上存在上皮细胞或为缓解症状而接受了微小乳管切除术。大多数患者患有导管内乳头状瘤（48.7%）、导管扩张症（15.8%）或两者兼而有之（13.2%）。其他良性病因发生在11.8%的患者中。8例患者患有癌症，其中1例是为缓解症状而接受手术。在那些患有良性疾病的患者中，98%的患者症状得到缓解，而1例患者的PND复发了两次。对于单导管PND且存在潜在恶性肿瘤的患者，术前检查和影像学检查可能并无可疑之处，因此，在这种情况下应考虑进行微小乳管切除术。
