血管加压素神经肽对大鼠社会认知的影响分析
Analysis of the influence of vasopressin neuropeptides on social recognition of rats.
作者信息
Sekiguchi R, Wolterink G, van Ree J M
机构信息
Department of Pharmacology, Rudolf Magnus Institute, Medical Faculty, University of Utrecht, The Nederlands.
出版信息
Eur Neuropsychopharmacol. 1991 May;1(2):123-6. doi: 10.1016/0924-977x(91)90713-5.
The facilitatory effect of vasopressin neuropeptides on social recognition of adult male rats was analyzed. The decrease of social investigation behaviors during a second encounter with the same juvenile rat served as index for social recognition. Treatment with desglycinamide-(Arg8)-vasopressin (6 mg.kg-1, s.c.) extended the time that adults recognize the same juvenile from 30 min to 24 h. Structure-activity studies revealed that the effect of vasopressin neuropeptides on social recognition resides in the 5-8 part of the AVP molecule. The peptide (pGlu4,Cyt6) AVP-(4-8) was more potent than DGAVP in this behavioral paradigm. These effects bear similarities with the memory enhancing effects of vasopressin neuropeptides as found in other test procedures.
分析了血管加压素神经肽对成年雄性大鼠社会识别的促进作用。在再次遇到同一只幼年大鼠时社会探究行为的减少被用作社会识别的指标。用去甘氨酰胺 -（精氨酸 8）- 血管加压素（6 毫克·千克-1，皮下注射）处理可使成年大鼠识别同一只幼年大鼠的时间从 30 分钟延长至 24 小时。构效关系研究表明，血管加压素神经肽对社会识别的作用存在于精氨酸加压素（AVP）分子的 5 - 8 部分。在这种行为范式中，肽（焦谷氨酸 4，半胱氨酸 6）AVP -（4 - 8）比去甘氨酰胺精氨酸加压素（DGAVP）更有效。这些作用与在其他测试程序中发现的血管加压素神经肽的记忆增强作用相似。
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