Ohno Naohito
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Cardiovasc Hematol Agents Med Chem. 2008 Jan;6(1):44-52. doi: 10.2174/187152508783329957.
CAWS is a mannoprotein-beta-glucan complex obtained from the culture supernatant of the fungal pathogen Candida albicans. CAWS exhibits various biological activities, and induces prominent vasculitis of the aortic valve and the coronary arteries in mouse. A significant difference was noted in the susceptibility to and the degree of vasculitis induction among mouse lines. The difference in cytokine production among mouse lines may be strongly related to that difference, namely, IL-6, IFN-gamma and TNF-alpha presumably act as positive factors, and IL-10, as a negative regulator. On the other hand, as a structural component of the inducing substance, the presence or absence of beta-1,2-mannose residues was suggested to be closely related to the activity. An understanding of the molecular mechanisms underlying this model could lead to the conquest of many modern diseases. This model is also expected to be useful for the development of new therapeutic drugs for vasculitis and cardiovascular diseases.
CAWS是一种从真菌病原体白色念珠菌的培养上清液中获得的甘露糖蛋白 - β - 葡聚糖复合物。CAWS具有多种生物学活性，并可在小鼠体内诱导主动脉瓣和冠状动脉出现显著的血管炎。在不同品系小鼠对血管炎的易感性和诱导程度上观察到了显著差异。小鼠品系之间细胞因子产生的差异可能与该差异密切相关，即白细胞介素 - 6、干扰素 - γ和肿瘤坏死因子 - α可能作为正向因子起作用，而白细胞介素 - 10作为负调节因子。另一方面，作为诱导物质的结构成分，β - 1,2 - 甘露糖残基的存在与否被认为与活性密切相关。对该模型潜在分子机制的理解可能会攻克许多现代疾病。该模型也有望用于开发治疗血管炎和心血管疾病的新型治疗药物。
