[摩洛哥拉巴特大学医院免疫抑制患者的隐球菌性脑膜炎]
[Cryptococcal neuromeningitis in immunosuppressed subjects at Rabat University Hospital (Morocco)].
作者信息
Aoufi S, Agoumi A, Seqat M
机构信息
Service de parasitologie, CHU Ibn Sina, Rabat, Maroc.
出版信息
Ann Biol Clin (Paris). 2008 Jan-Feb;66(1):79-81. doi: 10.1684/abc.2007.0176.
BACKGROUND
Cryptococcus neoformans is responsible for severe mycosis particularly in immunosuppressed patients.
OBJECTIVE
To describe the Moroccan cases of cryptococcal neuromeningitis.
MATERIAL AND METHODS
We retrospectively studied over a 12 year period (1993-2005) the cases of cryptococcal neuromeningitis diagnosed at the University Hospital of Rabat. The identification of Cryptococcus neoformans was made on cerebrospinal fluid samples after direct examination with the Indian ink and culture on Sabouraud's medium without cycloheximide.
RESULTS
Nine immunosuppressed patients had a cryptococcal neuromeningitis (7 men and 2 women). The average age was 33 years. Eight patients were infected with HIV and one was treated with steroids. The cryptococcosis reevaluated the HIV infection in 5 cases and 3 patients were already at the AIDS stage. The treatment based on amphotericin B was only effective in 3 patients.
CONCLUSION
These data incite us to optimise diagnosis tools and therapeutic strategies for cryptococcal neuromeningitis in Morocco.
背景
新型隐球菌是严重真菌病的病原体，尤其在免疫抑制患者中。
目的
描述摩洛哥隐球菌性脑膜炎病例。
材料与方法
我们回顾性研究了12年期间（1993 - 2005年）在拉巴特大学医院诊断的隐球菌性脑膜炎病例。新型隐球菌的鉴定是在脑脊液样本经印度墨汁直接检查并在不含放线菌酮的沙氏培养基上培养后进行的。
结果
9例免疫抑制患者患有隐球菌性脑膜炎（7例男性和2例女性）。平均年龄为33岁。8例患者感染了HIV，1例接受类固醇治疗。隐球菌病在5例中重新评估了HIV感染情况，3例患者已处于艾滋病阶段。基于两性霉素B的治疗仅对3例患者有效。
结论
这些数据促使我们优化摩洛哥隐球菌性脑膜炎的诊断工具和治疗策略。
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