Kitamura Yoshihisa, Fujitani Yoshika, Kitagawa Kouhei, Miyazaki Toshiaki, Sagara Hidenori, Kawasaki Hiromu, Shibata Kazuhiko, Sendo Toshiaki, Gomita Yutaka
Department of Pharmaceutical Care and Health Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Biol Pharm Bull. 2008 Feb;31(2):246-9. doi: 10.1248/bpb.31.246.
We examined the effect of chronic administration of imipramine and bupropion, monoamine reuptake inhibitors, on the duration of immobility in the forced swim test and serotonin (5-HT)(2A) receptor function in the form of 5-HT(2A) receptor mRNA levels in rats chronically treated with adrenocorticotropic hormone (ACTH). The immobility-decreasing effect of bupropion without imipramine did not influence the chronic ACTH treatment. The effect on the expression of 5-HT(2A) receptor mRNA of chronic ACTH treatment was decreased by bupropion, but not imipramine. These results suggest that bupropion has the effect of reducing immobility time in the forced swim test in the tricyclic antidepressant-resistant depressive model induced by chronic ACTH treatment in rats, and that decreased 5-HT(2A) receptor mRNA levels may be involved in this phenomenon.
我们研究了长期给予单胺再摄取抑制剂丙咪嗪和安非他酮，对促肾上腺皮质激素（ACTH）长期处理的大鼠在强迫游泳试验中的不动时间持续长短，以及以5-羟色胺（5-HT）（2A）受体mRNA水平形式存在的5-HT（2A）受体功能的影响。单独使用安非他酮而非丙咪嗪的减少不动时间的作用，并不影响长期ACTH处理。长期ACTH处理对5-HT（2A）受体mRNA表达的作用，被安非他酮降低，但未被丙咪嗪降低。这些结果表明，在大鼠慢性ACTH处理诱导的三环类抗抑郁药抵抗性抑郁模型中，安非他酮具有在强迫游泳试验中减少不动时间的作用，并且5-HT（2A）受体mRNA水平降低可能与这一现象有关。
