接受高效抗逆转录病毒治疗（HAART）的患者中，载脂蛋白C3（APOC3）基因多态性与血脂异常和脂肪萎缩的关联。
Association of APOC3 polymorphisms with both dyslipidemia and lipoatrophy in HAART-receiving patients.
作者信息
Bonnet Eric, Bernard Jacques, Fauvel Josette, Massip Patrice, Ruidavets Jean-Bernard, Perret Bertrand
机构信息
INSERM U563, Centre de Physiopathologie de Toulouse-Purpan, and Université Toulouse III Paul Sabatier, IFR30, Toulouse, F-31300, France.
出版信息
AIDS Res Hum Retroviruses. 2008 Feb;24(2):169-71. doi: 10.1089/aid.2007.0076.
The incidence and the magnitude of lipodystrophy and dyslipidemia in HIV-treated people reported in previous studies are very variable. Several predisposing factors have been identified, but there are few data on genetic factors. To search for a correlation between APOC3 polymorphisms and lipid disorders and lipodystrophy in HIV patients under d4T and protease inhibitors (PI)-containing HAART, we designed a monocenter, cross-sectional study in a University Hospital in Southern France during the period 2001-2004. Forty patients under HAART were included, with d4T for > or = 2 years and PI for > or = 1 year. We determined body mass composition by DXA, lipoprotein markers, and the -455/-482 apo C3 genotypes. Carriers of APOC3 variant alleles (-455 1/-482 1) displayed higher levels of triglycerides (3.72 vs. 2.57 mmol/liter), apo C3 (45.3 vs. 34.5 mg/liter), and apo E (130.2 vs. 66.5 mg/liter) and a lower fat mass (13.9 vs. 19.7%) than patients with nonvariant alleles (-455 0/-482 0). APOC3 polymorphisms might be associated with both dyslipidemia and lipoatrophy in HAART-treated patients.
先前研究报道的接受抗逆转录病毒治疗的HIV感染者中脂肪代谢障碍和血脂异常的发生率及严重程度差异很大。已确定了几个易感因素，但关于遗传因素的数据很少。为了探寻APOC3基因多态性与接受含司他夫定（d4T）和蛋白酶抑制剂（PI）的高效抗逆转录病毒治疗（HAART）的HIV患者的脂质紊乱及脂肪代谢障碍之间的相关性，我们于2001年至2004年期间在法国南部一家大学医院开展了一项单中心横断面研究。纳入了40例接受HAART治疗的患者，其服用d4T≥2年且服用PI≥1年。我们通过双能X线吸收法（DXA）、脂蛋白标志物以及-455 / -482载脂蛋白C3基因型来确定身体成分。与具有非变异等位基因（-455 0 / -482 0）的患者相比，携带APOC3变异等位基因（-455 1 / -482 1）的患者甘油三酯水平更高（3.72 vs. 2.57 mmol/升）、载脂蛋白C3水平更高（45.3 vs. 34.5 mg/升）、载脂蛋白E水平更高（130.2 vs. 66.5 mg/升）且脂肪量更低（13.9% vs. 19.7%）。APOC3基因多态性可能与接受HAART治疗患者的血脂异常和脂肪萎缩均相关。
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