胆汁淤积性瘙痒的治疗进展

Update on the treatment of the pruritus of cholestasis.

作者信息

Bergasa Nora V

机构信息

State University of New York at Downstate, USA.

出版信息

Clin Liver Dis. 2008 Feb;12(1):219-34, x. doi: 10.1016/j.cld.2007.11.009.

DOI:10.1016/j.cld.2007.11.009

PMID:18242506

Abstract

The pruritus of cholestasis is a difficult clinical problem to manage. It can be severe and interfere with sleep. Clinical behavioral studies have confirmed that the pruritus is mediated at least in part by endogenous opioids. Other neurotransmitter systems may be involved in the mediation of pruritus. Work continues to identify the mechanisms that mediate the pruritus and to develop specific drugs to treat this often maddening symptom.

摘要

胆汁淤积性瘙痒是一个难以处理的临床问题。它可能很严重并干扰睡眠。临床行为学研究证实，瘙痒至少部分是由内源性阿片类物质介导的。其他神经递质系统可能也参与瘙痒的介导过程。人们仍在继续研究介导瘙痒的机制，并研发特效药物来治疗这种常常令人抓狂的症状。