可卡因使用者长期禁欲期间的纵向心电图变化。
Longitudinal ECG changes in cocaine users during extended abstinence.
作者信息
Levin Kenneth H, Copersino Marc L, Epstein David, Boyd Susan J, Gorelick David A
机构信息
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA.
出版信息
Drug Alcohol Depend. 2008 May 1;95(1-2):160-3. doi: 10.1016/j.drugalcdep.2007.12.001. Epub 2008 Feb 1.
BACKGROUND
Cocaine lengthens electrocardiographic QTc, QRS and PR intervals through blockade of sodium and potassium channels, but changes during withdrawal have not been well studied.
METHODS
We recorded weekly electrocardiograms (ECGs) from 25 physically healthy cocaine users (84.0% men, mean [S.D.] age 34.7 [4.1] years, 9.0 [5.2] years of cocaine use, 9.4 [3.5] days of use in the 2 weeks prior to admission) over 3 months of monitored abstinence on a closed ward. Subjects had minimal current use of other drugs. Baseline ECGs were recorded 20.5 h [16.6] after last cocaine use.
RESULTS
Baseline QTc interval correlated positively with total amount of cocaine used and amount used per day in the 2 weeks prior to ward admission. There was a significant 10.5 ms [12.9] shortening of QTc interval during the first week of withdrawal, with no further significant changes thereafter. There were no significant changes in PR or QRS intervals.
CONCLUSIONS
These findings suggest that cocaine-associated QTc prolongation returns toward normal during the first week of cocaine abstinence.
背景
可卡因通过阻断钠通道和钾通道延长心电图QTc、QRS和PR间期，但戒断期间的变化尚未得到充分研究。
方法
我们在封闭病房对25名身体健康的可卡因使用者（84.0%为男性，平均[标准差]年龄34.7[4.1]岁，使用可卡因9.0[5.2]年，入院前2周使用9.4[3.5]天）进行了为期3个月的监测戒断，并每周记录心电图（ECG）。受试者目前极少使用其他药物。在最后一次使用可卡因后20.5小时[16.6]记录基线心电图。
结果
基线QTc间期与入院前2周使用的可卡因总量和每日使用量呈正相关。戒断第一周QTc间期显著缩短10.5毫秒[12.9]，此后无进一步显著变化。PR或QRS间期无显著变化。
结论
这些发现表明，在可卡因戒断的第一周，与可卡因相关的QTc延长恢复正常。
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