Ferlito Alfio, Rinaldo Alessandra, Silver Carl E, Shaha Ashok R, Fliss Dan M, Rodrigo Juan P, Elsheikh Mohamed N, Khafif Avi
Department of Surgical Sciences, ENT Clinic, University of Udine, Udine, Italy.
Auris Nasus Larynx. 2008 Dec;35(4):463-8. doi: 10.1016/j.anl.2007.11.008. Epub 2008 Feb 1.
Metastases to regional lymphatics are common in patients with well-differentiated thyroid cancer (WDTC) but the treatment of paratracheal adenopathy remains an issue of controversy among head and neck surgeons. The purpose of the current study was to review the indications for paratracheal neck dissection (PTND) in patients with WDTC. Most of the studies published in the English literature and examining PTND for WDTC were reviewed. No prospective randomized studies exist and thus this review examined the best available data. The occurrence of regional metastases in the paratracheal region is common in patients with WDTC and PTND is a safe and effective treatment for such metastases. Therapeutic PTND is the standard of care in patients with proven metastases to the paratracheal region. Elective PTND seems to be indicated in several groups of patients such as patients with clinically proven metastases in the lateral neck, even if the paratracheal region seems free of metastases on preoperative imaging studies. Male patients older than 45 years of age with thyroid cancer may also be candidates for this procedure. PTND may be indicated in several groups of patients with WDTC either as an elective or therapeutic procedure. Modern imaging and cytopathologic procedures may reveal suspected or proven metastatic disease in the paratracheal lymph nodes, particularly after previous surgery. However, the impact of such disease on the patients survival is questionable. More data regarding the benefit from this procedure in terms of regional control and long-term survival are needed.
分化型甲状腺癌(WDTC)患者出现区域淋巴结转移很常见,但气管旁腺病的治疗在头颈外科医生中仍是一个有争议的问题。本研究的目的是回顾WDTC患者气管旁颈部清扫术(PTND)的适应证。对英文文献中发表的大多数研究进行了回顾,这些研究探讨了WDTC的PTND。不存在前瞻性随机研究,因此本综述审查了现有的最佳数据。气管旁区域出现区域转移在WDTC患者中很常见,PTND是治疗此类转移的一种安全有效的方法。对于已证实气管旁区域转移的患者,治疗性PTND是标准治疗方法。选择性PTND似乎适用于几组患者,如临床证实侧颈部有转移的患者,即使术前影像学检查显示气管旁区域似乎没有转移。年龄大于45岁的男性甲状腺癌患者也可能是该手术的候选者。PTND可能适用于几组WDTC患者,作为选择性或治疗性手术。现代影像学和细胞病理学检查可能会发现气管旁淋巴结疑似或已证实的转移性疾病,尤其是在先前手术后。然而,这种疾病对患者生存的影响值得怀疑。需要更多关于该手术在区域控制和长期生存方面益处的数据。