自身免疫性疾病的造血干细胞移植：我们学到了什么？

Hematopoietic stem cell transplantation for autoimmune diseases: what have we learned?

作者信息

Burt Richard K, Testori Alessandro, Craig Robert, Cohen Bruce, Suffit Robert, Barr Walter

机构信息

Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

出版信息

J Autoimmun. 2008 May;30(3):116-20. doi: 10.1016/j.jaut.2007.12.010. Epub 2008 Feb 1.

DOI:10.1016/j.jaut.2007.12.010

PMID:18242956

Abstract

Numerous individuals and institutions throughout the world have contributed to the development of hematopoietic stem cell transplantation (HSCT) for autoimmune diseases. In this review, we will summarize what we have learned at our own institution (Northwestern University), and how it has guided our therapy. An emphasis will be placed on both the scientific basis for the development of autologous hematopoietic stem cell transplantation and a summary of the data in a variety of human diseases.

摘要

世界各地的众多个人和机构都为自身免疫性疾病的造血干细胞移植（HSCT）发展做出了贡献。在本综述中，我们将总结我们在自己的机构（西北大学）所学到的知识，以及这些知识如何指导我们的治疗。重点将放在自体造血干细胞移植发展的科学基础以及各种人类疾病的数据总结上。