Ozbek Zeynep, Makay Balahan, Unsal Erbil, Durak Ismet, Gunes Dilek, Anal Ozden, Ozer Erdener
Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey.
Cornea. 2008 Jan;27(1):117-9. doi: 10.1097/ICO.0b013e3181589309.
To report a case of chronic recurrent multifocal osteomyelitis (CRMO) with conjunctival involvement.
Retrospective chart review.
A 10-year-old girl who complained of fatigue and debilitating pain in both hips and legs for >1 year had recurrent episodes of redness and discharge in both eyes with little response to different topical medications. The diagnosis of CRMO was confirmed with the help of magnetic resonance imaging, bone scan, and bone biopsy results. She had moderate hyperemia and multiple discrete salmon-colored lesions in both palpebral and fornical conjunctivae. Biopsy revealed chronic inflammatory infiltration composed predominantly of lymphocytes forming a follicular pattern. Conjunctival lesions worsened during relapses of skeletal symptoms, improved during remission, and resolved shortly after the initiation of oral prednisolone therapy. No recurrence was observed during 16 months of follow-up.
Salmon-colored conjunctival lesions may accompany CRMO and respond favorably to systemic steroid therapy.
报告1例伴有结膜受累的慢性复发性多灶性骨髓炎（CRMO）病例。
回顾性病历审查。
一名10岁女孩抱怨双侧髋部和腿部疲劳及疼痛乏力超过1年，双眼反复出现发红和分泌物，对不同局部用药反应不佳。借助磁共振成像、骨扫描和骨活检结果确诊为CRMO。她双侧睑结膜和穹窿结膜有中度充血及多个散在的鲑鱼色病变。活检显示慢性炎症浸润，主要由淋巴细胞组成，呈滤泡样形态。结膜病变在骨骼症状复发时加重，缓解期改善，口服泼尼松龙治疗后不久消退。随访16个月未观察到复发。
鲑鱼色结膜病变可能伴随CRMO，对全身类固醇治疗反应良好。
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