Aydin Halil Ibrahim, Yozgat Yilmaz, Demirkaya Erkan, Olgun Abdullah, Okutan Vedat, Lenk Mustafa Koray, Ozcan Okan
Department of Pediatrics, Gülhane Military Medical Academy, Ankara, Turkey.
Turk J Pediatr. 2007 Oct-Dec;49(4):360-4.
The objective in this study was to determine whether there was any relation between leptin and vascular endothelial growth factor (VEGF) in children with cyanotic and acyanotic heart anomalies. The study group consisted of 18 children with cyanotic congenital heart disease (CHD) and 20 age-adjusted children with acyanotic CHD as controls. Serum VEGF and leptin levels were determined by enzyme-linked immunosorbent assay (ELISA). The mean VEGF level was 149.25+/-42.93 pg/ml (range 80.66-217.00) in the cyanotic group and 88.18+/-20.94 pg/ml (range 48.44-112.71) in the acyanotic group (p<0.001). The mean leptin level was 7.55+/-1.46 ng/ml (range 4.08-10.25) in the cyanotic group and 6.89+/-1.43 ng/ml (range 2.67-8.57) in the acyanotic group (p=0.168). There was a significant positive correlation (r=0.723, p<0.001) between VEGF and leptin levels in the cyanotic group while there was no correlation (r=0.235, p=0.348) in the acyanotic group. Arterial oxygen saturation (SaO2) was negatively correlated (r=-0.625, p<0.001) with VEGF, but not correlated with leptin (r=-0.207, p=0.211) in the cyanotic group. There was no correlation between VEGF, leptin and SaO2 in the acyanotic group. We conclude that it is likely that both VEGF and leptin have a role in the pathogenesis of angiogenesis in cyanotic CHD.
本研究的目的是确定患有青紫型和非青紫型心脏畸形的儿童中瘦素与血管内皮生长因子（VEGF）之间是否存在任何关联。研究组由18名患有青紫型先天性心脏病（CHD）的儿童和20名年龄匹配的非青紫型CHD儿童作为对照组成。通过酶联免疫吸附测定（ELISA）测定血清VEGF和瘦素水平。青紫组的平均VEGF水平为149.25±42.93 pg/ml（范围80.66 - 217.00），非青紫组为88.18±20.94 pg/ml（范围48.44 - 112.71）（p<0.001）。青紫组的平均瘦素水平为7.55±1.46 ng/ml（范围4.08 - 10.25），非青紫组为6.89±1.43 ng/ml（范围2.67 - 8.57）（p = 0.168）。青紫组中VEGF和瘦素水平之间存在显著正相关（r = 0.723，p<0.001），而非青紫组中无相关性（r = 0.235，p = 0.348）。在青紫组中，动脉血氧饱和度（SaO2）与VEGF呈负相关（r = -0.625，p<0.001），但与瘦素无相关性（r = -0.207，p = 0.211）。非青紫组中VEGF、瘦素和SaO2之间无相关性。我们得出结论，VEGF和瘦素可能在青紫型CHD血管生成的发病机制中起作用。
