Dai D X, Ishiguro E E
Department of Biochemistry and Microbiology, University of Victoria, British Columbia, Canada.
J Bacteriol. 1991 Jan;173(2):893-5. doi: 10.1128/jb.173.2.893-895.1991.
The lytD1 mutant of Escherichia coli exhibits temperature-sensitive growth which is attributed to cellular autolysis at the restrictive temperature. Either of two cloned phage lambda genes, identified as cI and cro, suppressed the lytD1(Ts) lysis phenotype, suggesting that lytD encodes a DNA-binding protein with a DNA-binding specificity similar to that of CI and Cro. LytD may be a repressor of a gene(s) involved in cellular autolysis.
大肠杆菌的lytD1突变体表现出温度敏感型生长，这归因于在限制温度下的细胞自溶。两个被鉴定为cI和cro的克隆噬菌体λ基因中的任何一个都抑制了lytD1（Ts）的裂解表型，这表明lytD编码一种DNA结合蛋白，其DNA结合特异性与CI和Cro相似。LytD可能是参与细胞自溶的一个或多个基因的阻遏物。
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