Perry Andrew J, Rimmer Kieran A, Mertens Haydyn D T, Waller Ross F, Mulhern Terrence D, Lithgow Trevor, Gooley Paul R
Department of Biochemistry and Molecular Biology, Bio21 Institute of Biotechnology and Molecular Science, University of Melbourne, Parkville, Victoria 3010, Australia.
Plant Physiol Biochem. 2008 Mar;46(3):265-74. doi: 10.1016/j.plaphy.2007.12.012. Epub 2008 Jan 3.
Proteins destined for the mitochondria required the evolution of specific and efficient molecular machinery for protein import. The subunits of the import translocases of the inner membrane (TIM) appear homologous and conserved amongst species, however the components of the translocase of the outer membrane (TOM) show extensive differences between species. Recently, bioinformatic and structural analysis of Tom20, an important receptor subunit of the TOM complex, suggests that this protein complex arose from different ancestors for plants compared to animals and fungi, but has subsequently converged to provide similar functions and analogous structures. Here we review the current knowledge of the TOM complex, the function and structure of the various subunits that make up this molecular machine.
定位于线粒体的蛋白质需要进化出特定且高效的蛋白质导入分子机制。内膜输入转位酶（TIM）的亚基在物种间似乎是同源且保守的，然而外膜转位酶（TOM）的组成成分在不同物种间存在广泛差异。最近，对TOM复合体重要受体亚基Tom20的生物信息学和结构分析表明，与动物和真菌相比，这种蛋白质复合体在植物中起源于不同的祖先，但随后趋同以提供相似的功能和类似的结构。在此，我们综述了目前关于TOM复合体、构成这一分子机器的各种亚基的功能和结构的知识。
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