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[纤溶酶及纤溶酶 - 链激酶等摩尔复合物的体外纤维蛋白溶解动力学]

[Kinetics of in vitro fibrinolysis by plasmin and a plasmin-streptokinase equimolar complex].

作者信息

Aĭsina R B, Zhitkova Iu V, Eremeev N L, Popova G Iu, Kazanskaia N F

出版信息

Ukr Biokhim Zh (1978). 1991 Jan-Feb;63(1):20-6.

PMID:1827551
Abstract

Kinetics of fibrinolysis by plasmin and plasmin streptokinase complex have been studied using fibrin gels formed from purified fibrin and human blood plasma. The gels were placed into buffer or blood plasma. The contributions of plasminogen and alpha 2-antiplasmin present or absent in both phases to the kinetics of fibrinolysis were quantitatively estimated. In the complex catalyzed fibrinolysis, plasminogen activation reaction dominated whereas in plasmin-catalyzed fibrinolysis, the inhibitor involved reaction, suppressing the process, prevailed.

摘要

利用从纯化纤维蛋白和人血浆形成的纤维蛋白凝胶,研究了纤溶酶和纤溶酶链激酶复合物的纤维蛋白溶解动力学。将凝胶置于缓冲液或血浆中。定量评估了两相中存在或不存在的纤溶酶原和α2-抗纤溶酶对纤维蛋白溶解动力学的贡献。在复合物催化的纤维蛋白溶解中,纤溶酶原激活反应占主导,而在纤溶酶催化的纤维蛋白溶解中,涉及抑制该过程的抑制剂反应占上风。

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