促性腺激素释放激素激动剂可提高授精前经充分预孵育的回收卵母细胞的妊娠潜能：一项比较研究。

GnRH agonist increases pregnancy potential of retrieved oocytes given adequate preincubation before insemination: a comparative study.

作者信息

Feldberg D, Goldman G A, Dicker D, Ashkenazi J, Shelef M, Goldman J A

机构信息

Sherman Fertility Institute, Department of Obstetrics Gynecology, Golda Meir Medical Center (Hasharon Hospital), Petah-Tikva, Israel.

出版信息

Eur J Obstet Gynecol Reprod Biol. 1991 Apr 16;39(2):111-6. doi: 10.1016/0028-2243(91)90073-t.

DOI:10.1016/0028-2243(91)90073-t

PMID:1828775

Abstract

Preincubation of oocytes aspirated from follicles in IVF-ET programs is a controversial approach. While some investigators recommend this technique others doubt its necessity. We have studied the embryo quality in 100 women, undergoing IVF-ET, in whom ovulation was induced by the combination of GnRH agonists (GnRHa) and menotropins and compared to a control group in whom ovulation was induced with menotropins alone. No statistically significant difference was noted with regard to the fertilization and cleavage rates as well as to the preincubation period. Significantly higher pregnancy rates (P less than 0.001) were encountered in the first group in comparison with the control group.

摘要

在体外受精 - 胚胎移植（IVF - ET）程序中，对从卵泡中吸出的卵母细胞进行预孵育是一种存在争议的方法。一些研究者推荐这种技术，而另一些人则怀疑其必要性。我们研究了100名接受IVF - ET的女性的胚胎质量，这些女性通过促性腺激素释放激素激动剂（GnRHa）和促性腺激素联合诱导排卵，并与仅用促性腺激素诱导排卵的对照组进行比较。在受精率、卵裂率以及预孵育时间方面未发现统计学上的显著差异。与对照组相比，第一组的妊娠率显著更高（P小于0.001）。