Tully Phillip J, Baker Robert A, Knight John L
Cardiac and Thoracic Surgical Unit, Flinders Medical Centre, Adelaide, South Australia, Australia.
J Psychosom Res. 2008 Mar;64(3):285-90. doi: 10.1016/j.jpsychores.2007.09.007.
This retrospective study examined the association between symptoms of depression, anxiety, and mortality risk following coronary artery bypass graft (CABG) surgery.
We assessed 440 CABG surgery patients' scores on the Depression Anxiety and Stress Scale (DASS) and followed up mortality status for a median of 5 years, 10 months.
There were 67 (15%) deaths overall during the follow-up period. Adjusted survival analysis showed that preoperative depressive symptoms were not associated with a significantly higher risk of mortality. Survival analysis with preoperative anxiety adjusted for covariates showed a significantly increased mortality risk [hazard ratio (HR)=1.88 (95% CI=1.12-3.17), P=.02].
Preoperative anxiety symptoms were significantly associated with increased mortality risk after adjustment for known mortality risk factors. Future research should further explore the simultaneous role of anxiety and depression on mortality following CABG.
本回顾性研究探讨冠状动脉搭桥术（CABG）后抑郁、焦虑症状与死亡风险之间的关联。
我们评估了440例接受CABG手术患者在抑郁焦虑压力量表（DASS）上的得分，并对其死亡状况进行了中位时间为5年10个月的随访。
随访期间共有67例（15%）死亡。校正生存分析显示，术前抑郁症状与显著更高的死亡风险无关。对术前焦虑进行协变量校正后的生存分析显示，死亡风险显著增加[风险比（HR）=1.88（95%置信区间=1.12 - 3.17），P = 0.02]。
在对已知死亡风险因素进行校正后，术前焦虑症状与死亡风险增加显著相关。未来研究应进一步探讨焦虑和抑郁在CABG术后死亡中的协同作用。
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